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The controversy around what is ‘normal’ in infants’ and children’s vitals was demonstrated in a 2011 systematic review by Fleming et al. and two cohort studies, one performed in Australia by O’Leary et al. and one in the US by Bonafide et al. Brennan et al. Our study supports previous work by Nijman et al.
A retrospective data review of the out-of-hospital cardiac arrest (OHCA) database from 2013-2015 demonstrated statistically significant differences in time from patient contact to administration of epinephrine between IV and IO groups (8.8 1] Table from Hamam et al. 9] Figure from Clemency et al. 3] Table from Tan et al.
1,2 However, the European TTM1 trial in 2013 showed similar outcomes for those cooled to 33 degrees Celsius compared to 36 degrees Celsius, leading to a 2015 AHA class I recommendation of “cooling between 32 degrees Celsius-36 degrees Celsius.” In a multisite retrospective cohort study, a study by Nishikimi, et al., N Engl J Med.
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