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Published 2013 Aug 15. Activation of the glucocorticoid receptor has an inhibitory effect on the enzyme phospholipase A2, with subsequent decreases in pro-inflammatory cytokines, prostaglandins, and at higher doses, B-cell and T-cell production. 5 ED physicians often reach for dexamethasone or prednisone, but what are their properties?
Heart rate (HR) and respiratory rate (RR) are THE major vital signs used in Advanced Paediatric LifeSupport ( APLS) guidance , sepsis guidelines , and Paediatric Early Warning Scores (e.g., Our study supports previous work by Nijman et al. What did previous studies show? and one in the US by Bonafide et al.
Background Despite conflicting literature to support some pharmacological therapies in out of hospital cardiac arrest, the American Heart Association (AHA) currently recommends obtaining vascular access intravenously or intraosseously in cardiac arrest. [1] Or in other words, is IO access inferior to IV access? minutes versus 5.4 minutes). [5]
1,2 However, the European TTM1 trial in 2013 showed similar outcomes for those cooled to 33 degrees Celsius compared to 36 degrees Celsius, leading to a 2015 AHA class I recommendation of “cooling between 32 degrees Celsius-36 degrees Celsius.” degrees Celsius. 5,6 In 2021, the TTM2 trial was published. degrees Celsius for 72 hours.
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