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REBEL Core Cast 108.0 – Angioedema

REBEL EM

Bradykinin Mediated Plasma globulins called kininogens release bradykinin and cause vascular permeability. Image: ( Morgan 2010 ) Features Absence of urticaria and pruritus Insidious onset (24-36 hours) ACE Inhibitors Inhibition of ACE hinders the degradation of bradykinin and can lead to idiosyncratic angioedema.

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emDOCs Podcast – Episode 81: Hemophilia

EMDocs

A 2013 study found oral mucosal and head bleeding due to injury were most common in those < 6 months. The patient’s plasma is mixed with normal pooled plasma (NPP) which adds sufficient clotting factors to overcome the deficiency. Each unit of FVIII/kg raises the plasma FVIII level by 2%. Plummer ES, et al.

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ToxCard: Chronic Organophosphate Toxicity

EMDocs

Boostani R, Mellat A, Afshari R, et al: Delayed polyneuropathy in farm sprayers due to chronic low dose pesticide exposure. Published 2013 Dec 9. PMID: 23163581] Muñoz-Quezada MT, Lucero BA, Iglesias VP, et al. These are send-out labs with turn-around times that make them unlikely to affect the ED course. McGraw-Hill Education.

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ToxCard: Acute Organophosphate Toxicity

EMDocs

8 Plasma butyrylcholinesterase (“pseudocholinesterase”) activity Easier to assay and is more widely available Red cell acetylcholinesterase (“true cholinesterase”) activity More accurate and specific Management: Patients require immediate intervention if there is concern for acute organophosphate poisoning. 2013; 6:524. BMC Res Notes.

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EM@3AM: CSF Leak

EMDocs

Although the concentration of chloride in the CSF is slightly higher than in plasma, measuring chloride (B) is not an accurate way to detect the presence of CSF. 2013 Mar;40(2):144-57. Callen AL, Timpone VM, Schwertner A, Zander D, Grassia F, Lennarson P, Seinfeld J, Lillehei KO, Birlea M, Thaker AA. Can J Neurol Sci.

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An EM Resident’s Guide to Basic Airway Management

Core EM

The 3/3/2 rule: Figure 3: how to perform the 3/3/2 rule (Image modified from UpToDate.com) If the patient has less than the specified measurement of 3, 3, or 2 fingers in these parameters, this is very specific (95%) for having a more difficult intubation (Mahmoodpoor, 2013)–although only about 25% sensitive.

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EM@3AM: Neurosyphilis

EMDocs

The development of an inflammatory process is largely due to the infiltration of lymphocytes and plasma cells which ultimately result in nerve damage (e.g., Rosh Review Website Link References: Tudor ME, Al Aboud AM, Leslie SW, Gossman W. doi:10.1056/NEJMra1906228 Ha T, Tadi P, Leslie SW, et al. In: StatPearls. N Engl J Med.

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