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The overall incidence of biphasic reactions is unknown with rates quoted from < 0.5% up to 23% ( Lieberman 2005 , Rohacek 2014 , Tole 2007 , Grunau 2014 ). This varied incidence can be due to inconsistent definitions or inclusion of mild reactions. Which patients are at risk for experiencing biphasic reactions?
Hypersensitivity/dermatologic: GLP-1 agonists are synthetic peptides; may lead to antibody formation and allergicreaction/injection site reaction. Reactions are usually minor: transient warmth, pruritis at injection site that resolves. 2014 Fall-Winter;11(3-4):202-30. Shetty R, Basheer FT, Poojari PG, et al.
10 This procedure has well-described rare complications including infection, blood loss, allergicreaction, arrhythmia, pneumothorax if approaching via the internal jugular vein, embolization of the device, and pulmonary artery perforation or dissection. Published May 2014. Angermann CE, Assmus B, Anker SD, et al.
2 Outcomes of patients presenting with ischemic stroke who received MRI as initial imaging modality have demonstrated similar outcomes to those with initial CTA, with Kim et al. In a study of 17,903 CTAs ordered in the ED, Tu et al. 8 The data in Mayer et al. 9 A later assessment of the VAN score in Beume et al.
Cataldi, Mauro, et al. ” History of Allergy 100 (2014): 214-226. Gutermuth, Jan, et al. “111 years of allergen-immunotherapy: a long and successful history of the only available disease-modifier in allergic diseases.” Development of neffy, an Epinephrine Nasal Spray, for Severe AllergicReactions.
Sometimes it seems like the world is out to get us: bees in our garden, pollen in the air, nuts in our brownies, any number of other things that could trigger an allergicreaction ranging from itchy eyes and a runny nose all the way to anaphylaxis. Hurley, Sadhbh, et al. Lv, Jia-jie, et al. Marichal, Thomas, et al.
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