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Thrombotic Thrombocytopenic Purpura (TTP)

Core EM

Joly, 2017; Sawler, 2020) Fresh frozen plasma (FFP) (contains ADMTS-13) may be used to supplement ADAMTS-13 if there is a delay in initiating TPE in the emergency department (i.e. Decreases production of anti-ADAMTS13 antibodies by removing the B cells that mature into autoantibody-secreting plasma cells. J Clin Med.

Plasma 246
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ToxCard: Iron

EMDocs

Antidote : Deferoxamine is a chelating agent derived from Streptomyces pilosus ; binds free iron from plasma and iron inside of cells. Coagulopathy: Parenteral vitamin K and/or fresh frozen plasma (FFP) as clinically indicated. McGraw Hill; 2016. 2 L/hr in adults. 1 Deferoxamine is safe in children. mg of elemental iron.

E-9-1-1 76
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Unstable Pelvic Trauma Patient: ED Presentations, Evaluation, and Management

EMDocs

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. McGraw Hill; 2016. Published 2016 May 18. Published 2016 May 18. Published June 6, 2016. Pelvis Injuries. Radiopaedia.org.

ED 54