2016 and Plasma - Paramedicine Now

Thrombotic Thrombocytopenic Purpura (TTP)

Core EM

JANUARY 25, 2024

Joly, 2017; Sawler, 2020) Fresh frozen plasma (FFP) (contains ADMTS-13) may be used to supplement ADAMTS-13 if there is a delay in initiating TPE in the emergency department (i.e. Decreases production of anti-ADAMTS13 antibodies by removing the B cells that mature into autoantibody-secreting plasma cells. J Clin Med. 2020;193:53-59.

Plasma

Plasma Frozen Plasma Emergency Department FFP

Acute Transverse Myelitis in Children

Pediatric EM Morsels

JUNE 14, 2024

(Tavasoli 2018, Wolf 2012) More common in adults; children comprise 20% of total cases (Pidcock 2007, Wang 2019) Bimodal age distribution (Absoud 2016) Children < 5 years Children > 10 years Symptoms evolve over 2-4 days and peak at 5-6 days (Absoud 2016) ATM may occur alone OR as part of another disorders (e.g.

Plasma

Plasma ALS OR EMS

Transfusion Reactions

Core EM

OCTOBER 16, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction

Allergic Reaction Plasma ED Epinephrine

Penetrating chest trauma

Don't Forget the Bubbles

JUNE 30, 2023

This was a randomised controlled multisite study comparing resuscitation of trauma patients requiring massive transfusion using either 1:1::1 or 1:1:2 ratios of platelets to plasma to red blood cells. A recent review was conducted on Trauma Quality Improvement Program data between 2014 and 2016. to −0.5%]; P = 0.03.).

E-9-1-1

E-9-1-1 FFP Plasma Emergency Department

Transfusion Reactions

Core EM

OCTOBER 2, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction

Allergic Reaction Plasma ED Epinephrine

Resident Journal Review: Massive Transfusion Protocols (MTPs) in Traumatic Hemorrhage

AAEM RSA

APRIL 1, 2021

2,3 Here we examine some of the evidence behind the various components of MTPs, specifically calcium and factor VIIa, and the ratios in which the main products of red blood cells, plasma, and platelets should be administered. 2016 May 1;202(1):182-7. Holcomb JB, Tilley BC, Baraniuk S, et al. 248(3):447-58. Ann Emerg Med. J Surg Res.

E-9-1-1

E-9-1-1 Plasma ACS ALS

Postpartum Hemorrhage: The Chapter We Skipped.

FOAMfrat

AUGUST 15, 2024

Moreover, LTOWB also allows us to administer platelets and plasma, in addition to red cells, to promote clotting and homeostasis. If you don't have access to LTOWB and are administering component therapies such as PRBCs or plasma, this is still incredible and I highly encourage it! September 09, 2016; Accessed: December 16, 2016.

Plasma

Plasma Ambulance ALS Emergency Department

ToxCard: Iron

EMDocs

DECEMBER 6, 2024

Antidote : Deferoxamine is a chelating agent derived from Streptomyces pilosus ; binds free iron from plasma and iron inside of cells. Coagulopathy: Parenteral vitamin K and/or fresh frozen plasma (FFP) as clinically indicated. McGraw Hill; 2016. 2 L/hr in adults. 1 Deferoxamine is safe in children. mg of elemental iron.

E-9-1-1

E-9-1-1 Frozen Plasma Plasma Overdose

Managing raised intracranial pressure in severe traumatic brain injury – the basics

Don't Forget the Bubbles

AUGUST 12, 2024

Hypertonic saline contains a higher sodium concentration than normal plasma and interstitial fluid. Published 2016 Feb 4. The osmolarity is also increased in the kidneys, which leads to diuresis. Hence, it’s important to monitor blood pressure to avoid any episodes of hypotension after mannitol. World J Crit Care Med. 2016;5(1):36-46.

ALS

ALS Emergency Department Plasma OR

Profound ST depression in II, III, aVF

Dr. Smith's ECG Blog

JULY 27, 2023

Peak plasma concentration of amphetamines is rapid ( within minutes ) following inhalation or injection. PEARL #3: The pathophysiologic mechanism for producing amphetamine-induced acute MI is unclear ( Bazmi et al — SQUMJ 17(10); e31-37, 2017 — and — Sinha et al — Case Rep Cardiol, 2016 ).

Coronary

Coronary ACS Naloxone Plasma

Unstable Pelvic Trauma Patient: ED Presentations, Evaluation, and Management

EMDocs

JUNE 3, 2023

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. McGraw Hill; 2016. Published 2016 May 18. Published 2016 May 18. Published June 6, 2016. Pelvis Injuries. Radiopaedia.org. doi:10.1097/TA.0b013e3182ab0cde

ED

ED Operating Room ALS Frozen Plasma

Andexxa Vs 4F-PCC in ICH: An Ongoing Debate

REBEL EM

NOVEMBER 28, 2022

Xian 2019) 4-Factor Prothrombin Complex Concentrates (4F-PCC), or K-Centra, is a derivative of human plasma and is explicitly used to reverse vitamin K antagonists such as warfarin and non-specifically in the reversal of DOACs. Andexanet alfa (AA) is a decoy protein specific to the emergent reversal of Factor Xa inhibitor-associated bleeding.

OR

OR Plasma ALS EMS

Complex Regional Pain Syndrome

Don't Forget the Bubbles

AUGUST 2, 2023

Pro-inflammatory states may also play a role, as patients with CRPS have significantly higher levels of plasma cytokines and chemokines. carried out a retrospective chart review of children with CRPS presenting to a paediatric Chronic Pain Clinic in Canada over a 5-year period (2012 to 2016). Published 2016 Apr 29.

MPD

MPD ALS Plasma OR

Sepsis Updates Relevant to the Emergency Physician

EMDocs

DECEMBER 18, 2023

The first was the suggestion to use balanced crystalloid fluids, such as lactated ringers or plasma-lyte, instead of normal saline. 1 This is a change from the 2016 SSC guidelines which suggested against corticosteroids. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

E-9-1-1

E-9-1-1 ALS Emergency Department Plasma

Trifecta: Amniotic Fluid Embolism

FOAMfrat

NOVEMBER 25, 2024

Resuscitating patients with low titer O whole blood or with component therapy in a ratio of 1:1:1, with packed red blood cells, platelets, and plasma, is impactful as it will help promote the restoration of circulation and add platelets and hemoglobin to the depleted store. They are no joke. Pacheco, L. Saade, G., & Hankins, G.

Epinephrine

Epinephrine CPR Operating Room Plasma

Paramedicine Now

Thrombotic Thrombocytopenic Purpura (TTP)

Acute Transverse Myelitis in Children

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Transfusion Reactions

Penetrating chest trauma

Transfusion Reactions

Resident Journal Review: Massive Transfusion Protocols (MTPs) in Traumatic Hemorrhage

Postpartum Hemorrhage: The Chapter We Skipped.

ToxCard: Iron

Managing raised intracranial pressure in severe traumatic brain injury – the basics

Profound ST depression in II, III, aVF

Unstable Pelvic Trauma Patient: ED Presentations, Evaluation, and Management

Andexxa Vs 4F-PCC in ICH: An Ongoing Debate

Complex Regional Pain Syndrome

Sepsis Updates Relevant to the Emergency Physician

Trifecta: Amniotic Fluid Embolism

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