REBEL EM

MAY 25, 2023

Ann Emerg Med 2017 [6] This was a retrospective database review of 7521 traumatic brain injury patients SBP target ≥90mmHg resulted in a mortality of 7.8% Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 ratio and Mortality in Patients with Severe Trauma: The PROPPR Randomized Clinical Trial. Ann Emerg Med.

E-9-1-1 145

E-9-1-1 Plasma ALS OR 145

The Skeptics' Guide to EM

APRIL 6, 2019

In contrast, protamine could be used for heparin and LMWH reversal and vitamin K, fresh frozen plasma and prothrombinase complex concentrate could be used to reverse coumadin ( Hunt and Levi BMJ 2018 ). The full study cohort of 503 patients has since been published ( Pollack et al NEJM 2017 ) and we are in the same place we were in 2015.

Frozen Plasma 130

Frozen Plasma Plasma ALS EMS 130

EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] 2] This linking group can be either an amide (e.g., lidocaine) or an ester (e.g.,

E-9-1-1 92

E-9-1-1 Plasma Epinephrine Life Support 92

Don't Forget the Bubbles

JUNE 30, 2023

This was a randomised controlled multisite study comparing resuscitation of trauma patients requiring massive transfusion using either 1:1::1 or 1:1:2 ratios of platelets to plasma to red blood cells. Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: design, rationale and implementation. 2017 Dec;83(6):1136-1141.

E-9-1-1 139

E-9-1-1 FFP Plasma Emergency Department 139

EMDocs

JUNE 12, 2024

Two randomized controlled trials by Moore et al found that prehospital plasma administration in trauma patients is associated with hypoCa (53% vs 36%). How does this impact the prehospital environment? Prehospital blood product transfusion increases risk of hypoCa. J Trauma Acute Care Surg. doi:10.1097/TA.0000000000002570 doi:10.1097/ta.0000000000001333

ALS 89

ALS FFP Plasma Emergency Department 89

REBEL EM

JUNE 26, 2023

Reversal of Trauma-Induced Coagulopathy Using First-Line Coagulation Factor Concentrates or Fresh Frozen Plasma (RETIC): A Single-Centre Parallel-Group, Open-Label Randomised Trial. Lancet Haematol 2017. PMID: 36942533 Innerhofer P et al. PMID: 28457980 Jehan F et al.

FFP 145

FFP Frozen Plasma ALS Plasma 145

FOAMfrat

AUGUST 15, 2024

Moreover, LTOWB also allows us to administer platelets and plasma, in addition to red cells, to promote clotting and homeostasis. If you don't have access to LTOWB and are administering component therapies such as PRBCs or plasma, this is still incredible and I highly encourage it! 2017 May 27. 389 (10084):2105-2116.

Plasma 69

Plasma Ambulance ALS Emergency Department 69

EMDocs

SEPTEMBER 7, 2023

DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. Pharmacokinetics: 2 No minimal toxic dose has been established, however, doses up to 22 mg seem to be safe for adults from the available literature. JAMA , vol. 15, 15 Apr. link] Robinson, Corie N.,

E-9-1-1 65

E-9-1-1 ALS Emergency Department Plasma 65

ACEP Now

NOVEMBER 16, 2023

Fresh frozen plasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.” 6 Balloon tamponade (i.e.,

Frozen Plasma 52

Frozen Plasma FFP ALS Plasma 52

Dr. Smith's ECG Blog

JULY 27, 2023

Peak plasma concentration of amphetamines is rapid ( within minutes ) following inhalation or injection. PEARL #3: The pathophysiologic mechanism for producing amphetamine-induced acute MI is unclear ( Bazmi et al — SQUMJ 17(10); e31-37, 2017 — and — Sinha et al — Case Rep Cardiol, 2016 ).

Coronary 52

Coronary ACS Naloxone Plasma 52

EMDocs

JUNE 3, 2023

For a broader overview of pelvic trauma, please review Dr. Lupez’s 2017 article here: [link]. Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. Published 2017 Jan 18. Published 2017 Oct 12.

ED 54

ED Operating Room ALS Frozen Plasma 54

EMDocs

AUGUST 7, 2023

Acute Aortic Dissection (AAD) A meta-analysis found that plasma D-dimer level <500 ng/mL is useful for identifying patients who are unlikely to have an AAD and do not require further aortic imaging. 2017 Nov;70(5):758]. 9 Additionally, a D-dimer level in the evaluation of AAD is most useful within 24 hours of symptom onset.

E-9-1-1 69

E-9-1-1 ALS Plasma OR 69

Don't Forget the Bubbles

JULY 5, 2023

SCD, therefore, is not only a mechanical disease but there are also many other cellular and plasma factors as well as endothelial interaction that generate chronic inflammation. Pediatr Allergy, Immunol Pulmonol 2017; 30: 191–201. Management of sickle cell disease: A review for physician education in Nigeria (Sub-Saharan Africa).

E-9-1-1 126

E-9-1-1 ACS OR ICU 126

EMDocs

MARCH 4, 2024

1 GGT is an enzyme located on the plasma membrane of hepatocytes that is involved in the regeneration of glutathione. doi:10.1136/gutjnl-2017-314924 Kunutsor SK. If ALP is elevated in conjunction with aminotransferases, the source may be assumed to be biliary, and further confirmation of the source is not required. 2018;67(1):6-19.

Emergency Department 86

Emergency Department E-9-1-1 ALS OR 86

EMDocs

MARCH 11, 2024

Although IgA has limited systemic circulation (~6 months), the memory B cells that are responsible for preventing cholera infection persist and can quickly expand and differentiate into plasmablasts and eventually the plasma cells, which can reseed protective antibodies upon antigen-contact activation. Published online August 25, 2017.

ED 89

ED OR ALS Plasma 89