Core EM

JANUARY 25, 2024

Joly, 2017; Sawler, 2020) Fresh frozen plasma (FFP) (contains ADMTS-13) may be used to supplement ADAMTS-13 if there is a delay in initiating TPE in the emergency department (i.e. 2018 Nov 30;2018(1):530-538. Prompt initiation of TPE has significantly decreased mortality for an initial episode of TTP from 90% to 10-20%.

Plasma 246

Plasma Frozen Plasma Emergency Department FFP 246

The Skeptics' Guide to EM

APRIL 6, 2019

In contrast, protamine could be used for heparin and LMWH reversal and vitamin K, fresh frozen plasma and prothrombinase complex concentrate could be used to reverse coumadin ( Hunt and Levi BMJ 2018 ). The FDA granted accelerated approval for andexanet alfa (Andexxa) in May of 2018.

Frozen Plasma 130

Frozen Plasma Plasma ALS EMS 130

ACEP Now

NOVEMBER 16, 2023

Fresh frozen plasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.” 2018:36(4):689-698.

Frozen Plasma 52

Frozen Plasma FFP ALS Plasma 52

REBEL EM

JUNE 26, 2023

Reversal of Trauma-Induced Coagulopathy Using First-Line Coagulation Factor Concentrates or Fresh Frozen Plasma (RETIC): A Single-Centre Parallel-Group, Open-Label Randomised Trial. J Trauma Acute Care Surg 2018. Lancet Haematol 2017. PMID: 28457980 Jehan F et al. PMID: 29664892 Zeeshan M et al.

FFP 144

FFP Frozen Plasma ALS Plasma 144

EMDocs

JUNE 3, 2023

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. Published October 9, 2018. Int J Environ Res Public Health. 2017;14(10):1217. Published 2017 Oct 12. doi:10.3390/ijerph14101217 Heilman, J.

ED 54

ED Operating Room ALS Frozen Plasma 54