EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] McGraw Hill Companies, Inc; 2019. lidocaine) or an ester (e.g.,

E-9-1-1 93

E-9-1-1 Plasma Epinephrine Life Support 93

EMDocs

JULY 11, 2023

The patient’s plasma is mixed with normal pooled plasma (NPP) which adds sufficient clotting factors to overcome the deficiency. If an inhibitor is present, it will inhibit the clotting factors in patient plasma and the NPP, and the clotting time remains prolonged. Each unit of FVIII/kg raises the plasma FVIII level by 2%.

Plasma 62

Plasma ALS OR Emergency Department 62

EMDocs

SEPTEMBER 7, 2023

DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. Metabolism of DEG adapted from Bessenhofer, et al. References: Abubukar et al. Nelson, et al. McGraw Hill, 2019. Conklin, Laura, et al. Nelson, et al. McGraw Hill, 2019.

E-9-1-1 66

E-9-1-1 ALS Emergency Department Plasma 66

Don't Forget the Bubbles

AUGUST 12, 2024

Hypertonic saline contains a higher sodium concentration than normal plasma and interstitial fluid. Ben Abdeljelil A, Freire GC, Yanchar N, et al. Doi:10.1056/NEJMc2201761 Kochanek PM, Adelson PD, Rosario BL, et al. 2022.0891 Kochanek PM, Tasker RC, Carney N, et al. 2019 Apr;20(4):404]. 2019 Apr;20(4):404].

ALS 75

ALS Emergency Department Plasma OR 75

ACEP Now

NOVEMBER 16, 2023

Fresh frozen plasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.” 2019:94(4):697-703.

Frozen Plasma 52

Frozen Plasma FFP ALS Plasma 52

EMDocs

JUNE 7, 2023

8 Plasma butyrylcholinesterase (“pseudocholinesterase”) activity Easier to assay and is more widely available Red cell acetylcholinesterase (“true cholinesterase”) activity More accurate and specific Management: Patients require immediate intervention if there is concern for acute organophosphate poisoning. Otherwise, provide supportive care.

E-9-1-1 84

E-9-1-1 ICU Emergency Department ED 84

EMDocs

JUNE 14, 2023

Boostani R, Mellat A, Afshari R, et al: Delayed polyneuropathy in farm sprayers due to chronic low dose pesticide exposure. PMID: 23163581] Muñoz-Quezada MT, Lucero BA, Iglesias VP, et al. These are send-out labs with turn-around times that make them unlikely to affect the ED course. References: Tintinalli, J. McGraw-Hill Education.

E-9-1-1 70

E-9-1-1 Emergency Department Plasma ACS 70

Don't Forget the Bubbles

JULY 5, 2023

SCD, therefore, is not only a mechanical disease but there are also many other cellular and plasma factors as well as endothelial interaction that generate chronic inflammation. Macharia AW et al. Sinkin JC, Wood BC, Sauerhammer TM, et al. Ware et al. 2019, 3 rd edition. Clinical Epidemiology of SCA in Africa.Am

E-9-1-1 126

E-9-1-1 ACS OR ICU 126

REBEL EM

NOVEMBER 28, 2022

Xian 2019) 4-Factor Prothrombin Complex Concentrates (4F-PCC), or K-Centra, is a derivative of human plasma and is explicitly used to reverse vitamin K antagonists such as warfarin and non-specifically in the reversal of DOACs. Ammar 2021, Pham 2022, Parsel 2022) However, Korebey et al. 2019, April 4). JAMA Netw Open.

OR 52

OR Plasma ALS EMS 52

EMDocs

JUNE 3, 2023

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. Glick Y, Knipe H, Hacking C, et al. Coccolini F, Stahel PF, Montori G, et al. doi:10.1186/s13017-017-0117-6 Anand T, El-Qawaqzeh K, Nelson A, et al.

ED 54

ED Operating Room ALS Frozen Plasma 54

Don't Forget the Bubbles

AUGUST 2, 2023

Pro-inflammatory states may also play a role, as patients with CRPS have significantly higher levels of plasma cytokines and chemokines. Cognitive behavioural therapy (CBT) In a study by Brinkers et al. A small, retrospective review by Brooke et al. More recently, Mesaroli et al. 2019 Dec;35(12):933-940.

MPD 98

MPD ALS Plasma OR 98

Don't Forget the Bubbles

MAY 15, 2023

This response varies between individuals, age groups and developmental stages, so a single plasma concentration cannot be defined. If there is clinical concern for hypoglycaemia, plasma glucose concentration should be measured. Learning point: Take a plasma glucose sample and ask the lab to run it urgently – time is sugar!

ED 103

ED Plasma OR ALS 103

EMDocs

MARCH 11, 2024

3 Between 1990 and 2019, there were approximately 3 million deaths due to cholera globally, indicating a significant public health issue. References Montero DA, Vidal RM, Velasco J, et al. 2023.1155751 Li X, Wu Y, Sun X, et al. 0054395 Qureshi K, Molbak K, Sandstrom A, et al. link] Roy SK, Hossain MJ, Khatun W, et al.

ED 90

ED OR ALS Plasma 90

EMDocs

NOVEMBER 2, 2024

The development of an inflammatory process is largely due to the infiltration of lymphocytes and plasma cells which ultimately result in nerve damage (e.g., Rosh Review Website Link References: Tudor ME, Al Aboud AM, Leslie SW, Gossman W. 2019 Oct 31;381(18):1789. doi:10.1056/NEJMra1906228 Ha T, Tadi P, Leslie SW, et al.

EMS 92

EMS E-9-1-1 Plasma ALS 92