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Anti-NMDA Receptor Encephalitis in Children and Adolescents

Pediatric EM Morsels

It is commonly missed during the first few ED visits. First line therapies for anti-NMBDA receptor encephalitis consists of… High dose steroids , IVIG, and PLEX – Therapeutic plasma exchange Only 50% of patient’s respond, and will require second line therapies such as Rituximab. Epub 2019 Dec 19. 2020 Feb;75:55-62.

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Anticoagulation Reversal

Core EM

Published 2019 Jun 6. Background Around 6 million people in the U.S. 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants: A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. Background Around 6 million people in the U.S. Clin Med (Lond).

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Congenital Syphilis

Pediatric EM Morsels

2019, there were 1,875 and this trend has continued to increase (2,157 case in 2020; 2,855 cases in 2021). Congenital Syphilis may still occur in patients presenting to your ED! Worldwide, congenital syphilis complicates about 1 million pregnancies / year. Hussain, 2023 ] Leads to >300,000 perinatal deaths / year globally.

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ToxCard: Local Anesthetic Systemic Toxicity

EMDocs

These medications are a vital tool in the care of ED patients, from simple local analgesia for a laceration repair to regional analgesia for painful procedures. Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] McGraw Hill Companies, Inc; 2019.

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ToxCard: Osmol Gap – Part 1

EMDocs

3 Measured in analytical testing : Laboratories measure plasma concentration using osmometers which measures values as a function of kilograms of solvent. New York Mcgraw-Hill Education; 2019. Choice of the best equation for plasma osmolality calculation: Comparison of fourteen formulae. Pharmacotherapy. 2003;23(9):1085-1086.

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Hypoglycaemia in the ED

Don't Forget the Bubbles

This response varies between individuals, age groups and developmental stages, so a single plasma concentration cannot be defined. How do I measure hypoglycaemia in the ED? If there is clinical concern for hypoglycaemia, plasma glucose concentration should be measured. Plasma glucose Beta-hydroxybutyrate (i.e.

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ToxCard: Diethylene Glycol

EMDocs

DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. “Diethylene Glycol” in Goldfrank’s Toxicologic Emergencies , 11e Eds. McGraw Hill, 2019. “Fomepizole” in Goldfrank’s Toxicologic Emergencies , 11e Eds. 1, 2010, pp.

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