EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] McGraw Hill Companies, Inc; 2019. Poisoning & Drug Overdose.

E-9-1-1 93

E-9-1-1 Plasma Epinephrine Life Support 93

REBEL EM

JUNE 26, 2023

Reversal of Trauma-Induced Coagulopathy Using First-Line Coagulation Factor Concentrates or Fresh Frozen Plasma (RETIC): A Single-Centre Parallel-Group, Open-Label Randomised Trial. J Trauma Acute Care Surg 2019. PMID: 36942533 Innerhofer P et al. Lancet Haematol 2017. PMID: 28457980 Jehan F et al.

FFP 145

FFP Frozen Plasma ALS Plasma 145

EMDocs

SEPTEMBER 7, 2023

DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. Elimination half-life data is not well established but increases in larger overdoses and as renal injury begins to occur. McGraw Hill, 2019. McGraw Hill, 2019. Schier, Capt. Nelson, et al.

E-9-1-1 66

E-9-1-1 ALS Emergency Department Plasma 66

EMDocs

DECEMBER 6, 2024

Historically, iron toxicity and exposure affected children in unintentional overdose disproportionately. 1 The incidence of iron overdose and iron ingestion related deaths has significantly decreased over time, likely attributable to federal regulation. McGraw Hill; 2019. 2 L/hr in adults. 1 Deferoxamine is safe in children.

E-9-1-1 76

E-9-1-1 Frozen Plasma Plasma Overdose 76