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Updates in High dose Insulin and Euglycemia Therapy (HIET) for the treatment of Beta-adrenergic Receptor and Calcium Channel Antagonists Overdose

Core EM

Background: An update to our 2015 post on HIET for beta-adrenergic receptor and calcium channel antagonists overdose. Beta-adrenergic receptor antagonists (Beta blockers, BB) and calcium channel antagonists (calcium channel blockers) are common drugs that can produce profound cardiac depression and shock when taken in overdose.

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ACMT Toxicology Visual Pearl: Needle to Necrosis

ALiEM

Recently, xylazine has gained attention in the media with increasing reports of xylazine-related overdose deaths in patients. When combined with illicit opioids such as heroin and fentanyl, xylazine may increase the risk of fatal overdose given the augmented sedation and respiratory depression effects [2]. Published 2021 Sep 17.

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Hypothermic Cardiac Arrest: Pearls and Pitfalls

EMDocs

The patient received 1 mg of epinephrine IV x2 with conversion of his rhythm to ventricular fibrillation (VF) for which he was defibrillated twice in the field. He requires low-dose epinephrine to maintain his mean arterial pressure (MAP) in the 60s mmHg and is transported to the cardiothoracic (CT) ICU. 2009;338:b2085. Resuscitation.

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What are treatment options for this rhythm, when all else fails?

Dr. Smith's ECG Blog

Epinephrine infusion was begun. These are also the most commonly reported findings in toxic overdoses with ventricular arrhythmias being reported as the leading cause of death. You can see Left Main and Proximal LAD obstruction, but with some flow, which is saving this patient's life. Subsequent PCI of the LMCA and LAD was performed.

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Calcium in Out-of-Hospital Cardiac Arrest

NAEMSP

After several cycles of defibrillation, epinephrine, and amiodarone, the patient remains in cardiac arrest. Additionally, low ionized calcium levels have been correlated with increasing mortality in sepsis and other critical illnesses in adults and children (Bora, Ramazan, Oznur, Emre, & Basar, 2021), (Sanchez, et al., Ramazan, K.,

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