ALiEM

NOVEMBER 29, 2023

Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome. In patients with minimal response to naloxone, xylazine toxicity may be suspected [10]. Published 2021 Sep 17. MMWR Morb Mortal Wkly Rep. 2021;70(37):1300-1302.

Naloxone 169

Naloxone Overdose Epinephrine ALS 169

REBEL EM

JUNE 5, 2023

from 2019 to 2021 (from 48,000 to 81,400 annual deaths), which includes prescription opioids (natural and semi-synthetic opioids and methadone), heroin, and synthetic opioids other than methadone including fentanyl (1). Background Information: Opioid overdose deaths have been increasing in the past twenty years. PMID 33392580.

Naloxone 98

Naloxone ED Overdose Emergency Department 98

Peter Canning

SEPTEMBER 19, 2024

Here in Connecticut, we witnessed a decline beginning in November 2021. Deaths are down by 20% in our state when comparing the 12-month period ending November 2021 with the 12-month period ending April 2024, and I have every indication that that trend is continuing through the summer. An unknown, but likely high number.

Naloxone 52

Naloxone Overdose First Responder OR 52

Peter Canning

OCTOBER 1, 2024

Is the decline in drug overdose deaths more related to the increased availability of naloxone, improved treatment for people who use drugs, or changes in the street drug supply, which while still quite toxic may be less so due to adulteration with other chemicals? A recent article in NPR, The pipeline of deadly fentanyl into the U.S.

Overdose 52

Overdose Naloxone OR 52

Peter Canning

MAY 22, 2024

Here in Connecticut, drug overdose deaths have been decreasing for the last two years (down 14% in 2023 from the 2021 high). Harm reduction and the availability of naloxone. Ten years ago when I responded to an overdose, I was the only one carrying naloxone. Drug overdose deaths are down 3.1% I can offer these possible answers.

Overdose 52

Overdose Naloxone First Responder OR 52

Peter Canning

DECEMBER 6, 2024

There has been much speculation and the answer probably doesnt lie with one factor but with many, including increased availability of naloxone, the efforts of harm reduction workers, the end of the COVID isolation, the trend away from injecting to snorting or smoking, a less toxic drug supply, and expanded treatment.

Overdose 52

Overdose Naloxone Emergency Department OR 52

ACEP Now

JULY 7, 2023

Since 2020 to 2021, the Drug Enforcement Administration has reported a sharp rise in xylazine use across the U.S., While naloxone can treat fentanyl overdose, overdose symptoms may persist when xylazine is involved. Xylazine is a veterinary sedative that has been increasingly implicated in overdose deaths throughout the United States.

Overdose 98

Overdose ALS Naloxone Emergency Department 98