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Transfusion Reactions

Core EM

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3%

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Transfusion Reactions

Core EM

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3%

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ToxCard: Crotalid Envenomation Part 2 – CroFab vs. AnaVip: What’s the Difference?

EMDocs

Accessed May 7, 2022. Background Crotalidae ovine polyvalent immune F(ab) (CroFab®) is the most widely available crotalid antivenom in the United States and is approved for severe crotalid envenomation with severe or progressive localized symptoms, systemic toxicity, and signs of hematologic toxicity on labs.

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emDOCs Podcast – Episode 94: GLP-1 Agonist Complications

EMDocs

American Gastroenterological Association issued a practice guideline in November 2022 recommending that semaglutide 2.4 Hypersensitivity reaction to a GLP-1 agonist, type 1 diabetes mellitus, and pregnancy. Reactions are usually minor: transient warmth, pruritis at injection site that resolves. How do they work?

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The PALACE Trial: Direct Oral PCN Challenge in Patients with Low-Risk PCN Allergy?

REBEL EM

What They Did: Parallel, 2-arm, noninferiority, open-label, multicenter, international randomized clinical trial Occurred in 6 specialized centers (3 in North America – US & Canada and 3 Outside of North America – Australia) Trial took place from June 2021 to December 2022 Used PEN-FAST to risk stratify patients. Paper: Copaescu AM et al.

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Pediatric Balanitis and Balanoposthitis

Pediatric EM Morsels

Balanitis and Balanoposthitis – Basics Terminology [Assim 2022, Dynamedex 2024, Perkins 2024] Balanitis – Inflammation of the glans penis Posthitis – Inflammation of the foreskin (prepuce) Balanoposthitis – Inflammation of both (ouch!) It’s even more distressing when the skin problem affects the penis.

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EM@3AM: Leukopenia

EMDocs

Well keep it short, while you keep that EM brain sharp. A previously healthy 23-year-old male with no medical or surgical history presents to the ED with generalized malaise and no energy, progressively getting worse over the last six weeks. 10^9/L) Moderate (0.50.9 10^9/L) Severe (< 0.5 10^9/L) Generalized leukopenia (i.e. Medications: 25.6%

E-9-1-1 94