EMDocs

SEPTEMBER 7, 2023

DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. Metabolism of DEG adapted from Bessenhofer, et al. References: Abubukar et al. Nelson, et al. Accessed August 2022. FDA Consumer Magazine , June 1981, [link] Accessed August 2022.

E-9-1-1 65

E-9-1-1 ALS Emergency Department Plasma 65

EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] McGraw Hill; 2022. 2] This linking group can be either an amide (e.g.,

E-9-1-1 92

E-9-1-1 Plasma Epinephrine Life Support 92

Don't Forget the Bubbles

AUGUST 12, 2024

Hypertonic saline contains a higher sodium concentration than normal plasma and interstitial fluid. Ben Abdeljelil A, Freire GC, Yanchar N, et al. Published 2022 Nov 20. Doi:10.1056/NEJMc2201761 Kochanek PM, Adelson PD, Rosario BL, et al. Published 2022 Mar 1. 2022.0891 Kochanek PM, Tasker RC, Carney N, et al.

ALS 75

ALS Emergency Department Plasma OR 75

Don't Forget the Bubbles

JUNE 30, 2023

This was a randomised controlled multisite study comparing resuscitation of trauma patients requiring massive transfusion using either 1:1::1 or 1:1:2 ratios of platelets to plasma to red blood cells. 2022 Dec;57(12):986-993. Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: design, rationale and implementation.

E-9-1-1 139

E-9-1-1 FFP Plasma Emergency Department 139

REBEL EM

NOVEMBER 28, 2022

Xian 2019) 4-Factor Prothrombin Complex Concentrates (4F-PCC), or K-Centra, is a derivative of human plasma and is explicitly used to reverse vitamin K antagonists such as warfarin and non-specifically in the reversal of DOACs. Ammar 2021, Pham 2022, Parsel 2022) However, Korebey et al. Crit Care 26, 180 (2022).

OR 52

OR Plasma ALS EMS 52

EMDocs

JUNE 3, 2023

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. Glick Y, Knipe H, Hacking C, et al. Published November 8, 2022. Coccolini F, Stahel PF, Montori G, et al. Published April 22, 2022.

ED 54

ED Operating Room ALS Frozen Plasma 54

ACEP Now

FEBRUARY 11, 2024

One side effect of this medication is that it can reduce the absorption of antiepileptic medications such as valproate, vigabatrin, and lamotrigine and reduce their plasma concentration, thus putting patients taking these medications at higher risk of seizure. Sodhi M, Rezaeianzadeh R, Kezouh A, et al. Bansal AB, Al Khalili Y.

Overdose 52

Overdose ACS Plasma ALS 52

EMDocs

MARCH 4, 2024

1 GGT is an enzyme located on the plasma membrane of hepatocytes that is involved in the regeneration of glutathione. Published online October 31, 2022:97-117. doi:10.1016/B978-0-323-48109-0.00036-5 Todd Taylor A, Wheatley M, Chung AS, et al. doi:10.3109/00365529309098282 Newsome PN, Cramb R, Davison SM, et al.

Emergency Department 86

Emergency Department E-9-1-1 ALS OR 86

EMDocs

NOVEMBER 2, 2024

The development of an inflammatory process is largely due to the infiltration of lymphocytes and plasma cells which ultimately result in nerve damage (e.g., Rosh Review Website Link References: Tudor ME, Al Aboud AM, Leslie SW, Gossman W. doi:10.1056/NEJMra1906228 Ha T, Tadi P, Leslie SW, et al. In: StatPearls. N Engl J Med.

EMS 91

EMS E-9-1-1 Plasma ALS 91

Don't Forget the Bubbles

OCTOBER 28, 2024

Karageorgos S, Ren D, Ranaweera M, et al. Major haemorrhage protocols typically include a mixture of packed red blood cells (pRBCs), platelets, and fresh frozen plasma (FFP). Re ferences Al-Jeabory M, Gasecka A, Wieczorek W, Mayer-Szary J, Jaguszewski MJ, Szarpak L. 2021.02.009 George S, Wake E, Jansen M, et al.

Frozen Plasma 72

Frozen Plasma FFP Plasma ALS 72

EMDocs

AUGUST 31, 2023

Plasma half-life of the F(ab’) 2 antivenom is significantly longer at 5.5 Accessed May 7, 2022. Accessed May 7, 2022. Accessed May 7, 2022. Accessed May 7, 2022. This size difference may lead to differences in the pharmacokinetic profiles of the two antibodies. 5 Figure 1. References: Ubani C, DeGelorm A, Sollee D.

Allergic Reaction 72

Allergic Reaction Plasma ALS EMS 72

FOAMfrat

SEPTEMBER 19, 2024

Along with inducing coagulopathy, venom toxins may contribute to local and/or systemic hemorrhage and plasma extravasation by means of basement membrane degradation within the vasculature. 2022, www.ncbi.nlm.nih.gov/books/NBK557565/. Other venom toxins carry a fibrinogenolytic effect which hinders coagulation (anticoagulation).

Emergency Department 90

Emergency Department Epinephrine OR Plasma 90

EMDocs

DECEMBER 18, 2023

Multiple studies published in 2022 have indicated that, despite disagreement surrounding prognostic accuracy, no such screening tool so far exists. The first was the suggestion to use balanced crystalloid fluids, such as lactated ringers or plasma-lyte, instead of normal saline. References Evans L, Rhodes A, Alhazzani W, et al.

E-9-1-1 65

E-9-1-1 ALS Emergency Department Plasma 65

EMDocs

MARCH 11, 2024

2 As of 2022 cholera was estimated to be responsible for over 4 million cases and 143,000 deaths each year, with a case fatality rate of 50% without timely and appropriate treatment. Published online November 14, 2022. Published online June 1, 2022. References Montero DA, Vidal RM, Velasco J, et al. Rehydration Therapy.

ED 89

ED OR ALS Plasma 89

The Skeptics' Guide to EM

SEPTEMBER 24, 2022

Date: September 20th, 2022 Reference: Menon et al. The Lancet 2022 Guest Skeptic: Professor Daniel Fatovich is an emergency physician and clinical researcher based at Royal Perth Hospital, Western Australia. Date: September 20th, 2022 Reference: Menon et al. Reference: Menon et al.

Plasma 100

Plasma ALS 100