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Tranq dope (fentanyl-xylazine combination): A new horizon in opioid withdrawal treatment

ALiEM

Bupe Allergy Buprenorphine induction has been the mainstay of emergency department treatment of opioid use disorder for more than a decade [11, 12]. Psychosis is now being witnessed with naloxone reversal in some cases, and the impact of these novel contaminants on withdrawal syndromes and wounds remain unknown. 2022 May;14(5).

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SGEM#374: Bad Habits – Medications for Opioid Use Disorder in the Emergency Department

The Skeptics' Guide to EM

Date: August 23rd, 2022 Reference: Schoenfeld et al. AEM August 2022 Guest Skeptic: Dr. Chris Bond is an emergency medicine physician and assistant Professor at the University of Calgary. Date: August 23rd, 2022 Reference: Schoenfeld et al. Reference: Schoenfeld et al.

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ACMT Toxicology Visual Pearl: Needle to Necrosis

ALiEM

Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome. In patients with minimal response to naloxone, xylazine toxicity may be suspected [10]. Journal of Addiction Medicine 16(5):p 595-598, 9/10 2022. Published 2022 Aug 19.

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Xylazine: “Zombie Drug” is an Emerging Threat

ACEP Now

CASE A 30-year-old woman presents to the emergency department with left arm pain from a chronic wound. While naloxone can treat fentanyl overdose, overdose symptoms may persist when xylazine is involved. Opioid overdoses involving xylazine in emergency department patients: a multicenter study. Clin Toxicol (Phila).

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Suicide Attempt in the Terminally Ill Cancer Patient with Advance Directive

ACEP Now

A middle-aged male with squamous cell carcinoma and extensive metastases is brought to the emergency department (ED) after being found unresponsive following a believed suicide attempt (SA) by methadone ingestion. Though paramedics administered naloxone, he remained somnolent. Emerg Med Australas. 2022 Jun;34(3):473-474.

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emDOCs Revamp – Acute Chest Syndrome

EMDocs

mg q20-30 min per dose) PRN naloxone in case of respiratory depression Some patients have SCD crises pain plan for reference Antimicrobials 11 Ceftriaxone + azithromycin if penicillin allergy for both children and adults. 2022 Jul 5;328(1):57-68. Am J Emerg Med. 2022 Aug;58:235244. Epub 2022 Jun 11. Am J Emerg Med.

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ToxCard: Naloxone – Pearls and Pitfalls

EMDocs

In the field, he was given 4 mg intranasal (IN) naloxone and rescue breaths via bag valve mask. He is administered 2mg intravenous (IV) naloxone and shortly after develops precipitated withdrawal with altered mental status, diaphoresis, vomiting, and diarrhea. When should a naloxone infusion be considered?