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Background: An update to our 2015 post on HIET for beta-adrenergic receptor and calcium channel antagonists overdose. Beta-adrenergic receptor antagonists (Beta blockers, BB) and calcium channel antagonists (calcium channel blockers) are common drugs that can produce profound cardiac depression and shock when taken in overdose.
Date: September 18, 2024 Reference: Dillon et al. August 20, 2024 Guest Skeptic: Dr. Chris Root is an emergency medicine and emergency medicine service (EMS) physician at the University of New Mexico, Albuquerque. Naloxone is a well-established medication used primarily for reversing opioid overdoses. JAMA Network Open.
AEM April 2024 Date: April 19, 2024 Guest Skeptic: Dr. Suchismita Datta. AEM April 2024 Date: April 19, 2024 Guest Skeptic: Dr. Suchismita Datta. A clinical decision tool called the STUMBL score was derived and validated by Battle et al in 2014 [3]. These risks are particularly higher in the elderly [2].
As it turns out, common sense likely rules the day when presented with patients whose low GCS is the result of a self-limited overdose toxidrome. References Gibbs KW, Semler MW, Driver BE, et al. Luo Z, Li Y, Li W, et al. 2024:e2415815. Knack SKS, Scott N, Driver BE, et al. Escobar GJ, Liu VX, Schuler A, et al.
There are many underlying causes, such as stroke, central nervous system depression (opioid overdose, etc.), 2024, www.ncbi.nlm.nih.gov/books/NBK536919/. Accessed 28 July 2024. Hopkins, Erin, et al. Accessed 28 July 2024. Accessed August 8, 2024. Accessed August 8, 2024. Accessed August 8, 2024.
In such cases — radiofrequency ablation of ectopic beats triggering malignant ventricular arrhythmias was needed for control of arrhythmic storm because the antiarrhythmic medications tried were ineffective ( Marrouche et al — JACC 5;43(9): 1715-20, 2004 ). The most common side effects of Quinidine is hypotension and QTc prolongation.
LoVecchio, Frank, et al. CDC: May 14, 2024 Drug Overdose Death Rates. Health care cost savings from Australian Poisons Information Centre advice for low risk exposure calls: SNAPSHOT 2. Clinical Toxicology , 58 (7), pp.752-757. “Poison control centers decrease emergency healthcare utilization costs.”
LoVecchio, Frank, et al. CDC: May 14, 2024 Drug Overdose Death Rates. Health care cost savings from Australian Poisons Information Centre advice for low risk exposure calls: SNAPSHOT 2. Clinical Toxicology , 58 (7), pp.752-757. “Poison control centers decrease emergency healthcare utilization costs.”
There have been documented cases of overdose, and of note, there is no known antidote. Sodhi M, Rezaeianzadeh R, Kezouh A, et al. Ahmann AJ, Capehorn M, Charpentier G, et al. Poison centers see nearly 1,500% increase in calls related to injected weight-loss drugs as people accidentally overdose. Accessed January 11, 2024.
Date: December 26, 2024 Reference: Steinhauser S et al. AEM December 2024 Guest Skeptic:Dr. Emergency departments (EDs) are often the first point of contact for patients experiencing opioid-related crises, ranging from overdose to withdrawal. Reference: Steinhauser S et al. Suchismita Datta.
He was admitted for a suspected kratom overdose and acute kratom withdrawal. 7 Most of the difficulty in identifying patients who have overdosed or are in acute withdrawal from kratom comes from the inability to test for it in commercial assays of blood or urine. link] Accessed December 4, 2024. He was discharged the next day.
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