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Therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) is the first-line treatment, by simultaneously supplying fresh ADAMTS13 and removing anti-ADAMTS13 autoantibodies. It is thus imperative that emergency physicians be able to recognize and properly treat this disease, especially in the absence of its classical presentation.
Published Online First: 24 June 2024. doi: 10.1136/archdischild-2024-327224 Six-year-old Rhaenyra is brought into the emergency department after being hit by a car. Major haemorrhage protocols typically include a mixture of packed red blood cells (pRBCs), platelets, and fresh frozen plasma (FFP).
Warfarin: vitamin K 10 mg IV and PCC or FFP. Fibrinogen level < 150 mg/dL: cryoprecipitate or fibrinogen concentrate (not FFP). Fibrinogen level < 150 mg/dL: cryoprecipitate or fibrinogen concentrate (not FFP). Prior to current therapies, mortality rates ranged between 50-100%. Imaging: Start with bedside chest x-ray.
Trauma is the most significant contributor to childhood mortality, with the mechanism changing with maturity and social development. In younger children, the predominant mechanism of inflicted injury is by shaking or beating, and most commonly, the abuser is a family member or caregiver. Do I have emergency blood available in the ED?
History of Present Illness The collateral history indicates that her symptoms began one week into her journey, but medical care was inaccessible at the time. The family reports no history of food allergies, insect bites, or contact with sick individuals. The patient did not receive pre-travel prophylaxis for malaria, hepatitis A, or yellow fever.
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