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emDOCs Podcast – Episode 113: Immune Checkpoint Inhibitor Adverse Events

EMDocs

Today on the emDOCs cast with Brit Long ( @long_brit) , we cover immune checkpoint inhibitors and adverse events. The post emDOCs Podcast Episode 113: Immune Checkpoint Inhibitor Adverse Events appeared first on emDOCs.net - Emergency Medicine Education. Immune checkpoint inhibitors: An emergency medicine focused review.

ACS 98
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Elder Male with Syncope

EMS 12-Lead

He denied any specific prodrome of gross palpitations, however did endorse feeling quite dizzy just before the event. Given no clinical prelude of anginal (or equivalent) descriptors, prior to the acute event, risk stratification of the ECG and Troponin was pursued via Echo and nuclear Myocardial Perfusion Imaging (MPI).

Coronary 290
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Dynamic OMI ECG. Negative trops and negative angiogram does not rule out coronary ischemia or ACS.

Dr. Smith's ECG Blog

Furthermore, if this occurs at all, it is a rare event. It is not small but rather large plaques, which may not be producing significant stenosis, that undergo rupture with acute occlusive thrombosis, resulting in myocardial infarction and other ischemic events. These are typical findings at sites of plaque rupture.

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Myths in Diagnosis of ACS

EM Didactic

Myth 1 Absence of Classic Chest Pain obviates the need for ACS work up The absence of chest pain in no way excludes the diagnosis of ACS. Around 33-50% of the patients with ACS present to the hospital without chest pain. Close to 20% of patients diagnosed with acute MI present with symptoms other than chest pain.

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Clinical Conundrum: Should a Troponin Routinely be Ordered in Patients with SVT?

REBEL EM

What Your Gut Says: The patient has a tachydysrhythmia which may be the presentation of acute coronary syndrome (ACS) even though the patient has no ischemic symptoms. There are other reasons aside from ACO for troponin elevations: Type 1: MI due to a spontaneous coronary atherosclerotic event. Send the troponin just to make sure.

Coronary 143
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SGEM#370: Listen to your Heart (Score)…MACE Incidence in Non-Low Risk Patients with known Coronary Artery Disease

The Skeptics' Guide to EM

Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter? Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter? If we thought about ACS, we brought them in. Date: June 30th, 2022 Reference: McGinnis et al. AEM June 2022. AEM June 2022.

Coronary 100
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Tranq dope (fentanyl-xylazine combination): A new horizon in opioid withdrawal treatment

ALiEM

That discussion can be deferred until the patient is stable, the risk of such an event is mitigated, and other medications can be given for their withdrawal symptoms and pain. DOI: Papudesi BN, Malayala SV, Regina AC. This month in JAAD Case Reports: August 2023: Xylazine and skin necrosis. 2023 Aug 1;89(2):231. Xylazine toxicity.

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