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In the acute setting, it is postulated that withdrawal may be brought on by the rapid reversal and displacement of opioid receptors from drugs such as naloxone (Narcan). Kruegel AC, Gassaway MM, Kapoor A, et al. Gold MS, Pottash AC. That is, they experienced nausea, vomiting, chills, myalgias, and diarrhea. J Med Chem.
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