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CRISPR-Cas13 Test Inexpensively and Rapidly Reveals HIV Viral Load

Medgadget

Study in journal ACS Nano : STAMP-Based Digital CRISPR-Cas13a for Amplification-Free Quantification of HIV-1 Plasma Viral Loads Via: Penn State By counting the signals, researchers can quantify the viral load in a sample. Credit: Provided by Weihua Guan.

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Tasty Morsels of Critical Care 010 | Cardiac disease in pregnancy

Emergency Medicine Ireland

Well, most commonly we’re going to see ACS. Pregnancy itself with its bump in plasma volume, reduced Hb and increased cardiac output is like one long exercise stress test. What can we expect to see in terms of cardiac disease?

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Episode 82 – When Normal Labs Aren’t Necessary

The Curious Clinicians

One well-known study bled volunteers to a hemoglobin of 5 g/dL, while keeping them isovolemic with albumin or plasma infusions. The subjects’ blood was less viscous than normal, due to the isovolemic replenishment with plasma and albumin, making it flow more easily. A patient with hemorrhagic shock has problems with both.

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Profound ST depression in II, III, aVF

Dr. Smith's ECG Blog

I did not think it was due to ACS, but we ordered an ED ECG immediately: What do you think? But in this case the clinical scenario is not right for acute ACS with OMI, and there is very high voltage, and the patient is very young, (though beware of young patients , even 29 year olds!! There is profound "inferior" ST Depression.

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Popular Antiobesity Medications Bring New Challenges to Emergency Physicians

ACEP Now

One side effect of this medication is that it can reduce the absorption of antiepileptic medications such as valproate, vigabatrin, and lamotrigine and reduce their plasma concentration, thus putting patients taking these medications at higher risk of seizure. ACS chemical neuroscience molecule spotlight on Contrave. ACS Chem Neurosci.

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ToxCard: Chronic Organophosphate Toxicity

EMDocs

doi:10.1080/10773525.2015.1123848 Povey AC, Rees HG, Thompson JP, Watkins G, Stocks SJ, Karalliedde L. Two assays available used to help confirm diagnosis, however, do not guide treatment Low levels of activity are consistent with organophosphate poisoning. 3 However, may be helpful in diagnosing the chronic toxicity forms. 2016;22(1):68-79.

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ToxCard: Acute Organophosphate Toxicity

EMDocs

8 Plasma butyrylcholinesterase (“pseudocholinesterase”) activity Easier to assay and is more widely available Red cell acetylcholinesterase (“true cholinesterase”) activity More accurate and specific Management: Patients require immediate intervention if there is concern for acute organophosphate poisoning. Toxicology. 2001;160(1-3):27-33.

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