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Clinical Conundrums: How Long Should We Monitor After Giving IM Epinephrine for Anaphylaxis?

REBEL EM

The overall incidence of biphasic reactions is unknown with rates quoted from < 0.5% This varied incidence can be due to inconsistent definitions or inclusion of mild reactions. Since half of biphasic reactions occur within the first 6-12 hrs ( Lee 2014 ) physicians often choose an observation time of 4-6 hrs.

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Cetirizine Vs Diphenhydramine For the Treatment of Acute Urticaria in the ED

REBEL EM

Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergic reactions. Article: Abella BS et al. Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review. Zuberbier, Torsten, et al. Ledford, D.

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The PALACE Trial: Direct Oral PCN Challenge in Patients with Low-Risk PCN Allergy?

REBEL EM

Paper: Copaescu AM et al. References: Copaescu AM et al. This practice is both resource and time intensive thus limiting the number of people who can actually have their penicillin allergy removed from their chart. A rapid, safe approach to confirming or refuting allergies is needed. JAMA Intern Med 2023. JAMA Intern Med 2023.

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Are Steroids really slow to act?

FOAMfrat

These steroids are undoubtedly part of the cocktail we reach for in patients presenting with acute asthma, allergic reactions, or anaphylaxis - and traditional clinical logic has taught us these drugs work to reduce inflammation in the airways and reduce bronchial mucus production. Namely, Solumedrol and Dexamethasone (Decadron).

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CT Angiography Head and Neck: Indications and Limitations

EMDocs

2 Outcomes of patients presenting with ischemic stroke who received MRI as initial imaging modality have demonstrated similar outcomes to those with initial CTA, with Kim et al. In a study of 17,903 CTAs ordered in the ED, Tu et al. 8 The data in Mayer et al. 9 A later assessment of the VAN score in Beume et al.

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EM@3AM: Leukopenia

EMDocs

Specific Considerations: Neutropenic Fever: 15 Definition: Absolute Neutrophil Count <500 or <1000 with predicted nadir of <500 in 48 hours AND Fever 38.3C (101F) or a temperature of 38.0C (100.4F) sustained over a one-hour period Treatment: Inpatient: Cefepime 2g IV q8hrs OR Meropenem 1g IV q8hrs OR Piperacillin/Tazobactam 4.5g

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Episode 161 Allergies Part 1: Pollens, nuts, & bugs

This Podcast Will Kill You

Sometimes it seems like the world is out to get us: bees in our garden, pollen in the air, nuts in our brownies, any number of other things that could trigger an allergic reaction ranging from itchy eyes and a runny nose all the way to anaphylaxis. Hurley, Sadhbh, et al. Lv, Jia-jie, et al. Marichal, Thomas, et al.

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