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The overall incidence of biphasic reactions is unknown with rates quoted from < 0.5% This varied incidence can be due to inconsistent definitions or inclusion of mild reactions. Since half of biphasic reactions occur within the first 6-12 hrs ( Lee 2014 ) physicians often choose an observation time of 4-6 hrs.
Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergicreactions. Article: Abella BS et al. Diphenhydramine versus nonsedating antihistamines for acute allergicreactions: a literature review. Zuberbier, Torsten, et al. Ledford, D.
Paper: Copaescu AM et al. References: Copaescu AM et al. This practice is both resource and time intensive thus limiting the number of people who can actually have their penicillin allergy removed from their chart. A rapid, safe approach to confirming or refuting allergies is needed. JAMA Intern Med 2023. JAMA Intern Med 2023.
These steroids are undoubtedly part of the cocktail we reach for in patients presenting with acute asthma, allergicreactions, or anaphylaxis - and traditional clinical logic has taught us these drugs work to reduce inflammation in the airways and reduce bronchial mucus production. Namely, Solumedrol and Dexamethasone (Decadron).
2 Outcomes of patients presenting with ischemic stroke who received MRI as initial imaging modality have demonstrated similar outcomes to those with initial CTA, with Kim et al. In a study of 17,903 CTAs ordered in the ED, Tu et al. 8 The data in Mayer et al. 9 A later assessment of the VAN score in Beume et al.
Specific Considerations: Neutropenic Fever: 15 Definition: Absolute Neutrophil Count <500 or <1000 with predicted nadir of <500 in 48 hours AND Fever 38.3C (101F) or a temperature of 38.0C (100.4F) sustained over a one-hour period Treatment: Inpatient: Cefepime 2g IV q8hrs OR Meropenem 1g IV q8hrs OR Piperacillin/Tazobactam 4.5g
Sometimes it seems like the world is out to get us: bees in our garden, pollen in the air, nuts in our brownies, any number of other things that could trigger an allergicreaction ranging from itchy eyes and a runny nose all the way to anaphylaxis. Hurley, Sadhbh, et al. Lv, Jia-jie, et al. Marichal, Thomas, et al.
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