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Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactionsAllergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3%
Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactionsAllergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3%
Most often occurs in uncircumcised males [Assim 2022] Buildup of sloughed and dead skin, microorganisms, and secretions between the foreskin and the glans Incidence in children shown to range from 0.05% up to 20% [Kayaba 1996, Hsieh 2006] Between 6% and 20% in uncircumcised men [Assim 2022, Perkins 2024] Pediatrics usually presents between 2y and 5y (..)
Bottom Line Up Top: Pretreatment is ineffective and unnecessary as it does not significantly reduce the risk of serious adverse reactions to contrast. Pretreatment should not delay imaging required for definitive diagnosis. Do you pretreat the patient prior to CT scan or proceed without delay and risk an allergicreaction?
It’s a severe, potentially life-threatening allergicreaction that can occur within minutes. Anaphylaxis is a word that strikes fear in the hearts of many. For those who have experienced it—or… The post Navigating Anaphylaxis: Causes, Symptoms, and Treatment appeared first on Paramedics World.
Sent by anonymous, written by Pendell Meyers A man in his late 40s presented to the ED with concern for allergicreaction after accidentally eating a potential allergen, then developing an itchy full body rash and diarrhea. In the ED he received methylprednisolone, diphenhydramine, and epinephrine for possible anaphylaxis.
Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergicreactions. Diphenhydramine versus nonsedating antihistamines for acute allergicreactions: a literature review. Resources: Banerji A, Long AA, Camargo CA Jr. Allergy Asthma Proc. Ledford, D.
The overall incidence of biphasic reactions is unknown with rates quoted from < 0.5% This varied incidence can be due to inconsistent definitions or inclusion of mild reactions. Since half of biphasic reactions occur within the first 6-12 hrs ( Lee 2014 ) physicians often choose an observation time of 4-6 hrs.
These steroids are undoubtedly part of the cocktail we reach for in patients presenting with acute asthma, allergicreactions, or anaphylaxis - and traditional clinical logic has taught us these drugs work to reduce inflammation in the airways and reduce bronchial mucus production. Namely, Solumedrol and Dexamethasone (Decadron).
What They Did: Parallel, 2-arm, noninferiority, open-label, multicenter, international randomized clinical trial Occurred in 6 specialized centers (3 in North America – US & Canada and 3 Outside of North America – Australia) Trial took place from June 2021 to December 2022 Used PEN-FAST to risk stratify patients.
63 This is because their definition of CI-AKI is an AKI that ensues within 48 hours of receiving IV contrast in the absence of any “other nephrotoxic factors.” 63 Since the definition of “other nephrotoxic factors” could be broad and difficult to control for in what has mostly been observational studies, this is a problematic diagnosis.
Specific Considerations: Neutropenic Fever: 15 Definition: Absolute Neutrophil Count <500 or <1000 with predicted nadir of <500 in 48 hours AND Fever 38.3C (101F) or a temperature of 38.0C (100.4F) sustained over a one-hour period Treatment: Inpatient: Cefepime 2g IV q8hrs OR Meropenem 1g IV q8hrs OR Piperacillin/Tazobactam 4.5g
Sometimes it seems like the world is out to get us: bees in our garden, pollen in the air, nuts in our brownies, any number of other things that could trigger an allergicreaction ranging from itchy eyes and a runny nose all the way to anaphylaxis. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis.
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