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Clinical Conundrums: How Long Should We Monitor After Giving IM Epinephrine for Anaphylaxis?

REBEL EM

This is called a biphasic reaction. The risk of a biphasic reaction is what keeps patients in the ED while being observed for a set period of time. The overall incidence of biphasic reactions is unknown with rates quoted from < 0.5% The American Journal of Emergency Medicine 2018 Aug;36(8):1480-1485 Shaker M, et al.