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REBEL Core Cast 108.0 – Angioedema

REBEL EM

Urticaria and pruritus = MAST CELL mediated, which is treated like a standard allergic reaction. Without the C1 inhibitor, the plasma-kallikrein-kinin system produces more bradykinin. Urticaria and pruritus = MAST CELL mediated, which is treated like a standard allergic reaction. N Engl J Med. 2015; 372(5):418-25.

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ToxCard: Crotalid Envenomation Part 2 – CroFab vs. AnaVip: What’s the Difference?

EMDocs

Plasma half-life of the F(ab’) 2 antivenom is significantly longer at 5.5 F(ab) is smaller, consisting of a single antigen binding site, while F(ab’) 2 consists of two antigen-binding sites linked together by an antibody “hinge” region. This size difference may lead to differences in the pharmacokinetic profiles of the two antibodies.