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Pathophysiology Primary injury happens at the time of the traumatic event or shortly after in the high cervical to mid-thoracic spine. Both norepinephrine and epinephrine can be used. Epinephrine is key if there is significant bradycardia. Tenenbein M, Macias CG, Sharieff GQ, et al, eds. 5 th Edition. Neurogenic Shock.
1-4 The PDPs, phenylephrine and epinephrine, result in vasoconstriction and increased cardiac contractility. They can be associated with side effects such as reflex bradycardia, decreased stroke volume in phenylephrine, tachycardia and hypertension associated with epinephrine. Paper: Singer S, et al. Am J Emerg Med. 2022 Sep 5.
Read More EMCrit: Podcast 145 – Awake Intubation Lecture from SMACC ERCast: Angioedema References: Baş M et al. PMID 25629740 Hassen GW et al. PMID 23062323 Kostis JB et al. PMID 16043683 McCormick M et al. PMID 20954277 Sinnert R et al. Zuraw et al. N Engl J Med. 2015; 372(5):418-25. 2013;24:53-66.
Attention was turned to the consideration of severe coronary vasospasm as the inciting event for cardiopulmonary arrest and the nidus for refractory ventricular fibrillation. Traditional Advanced Cardiovascular Life Support (ACLS) medications, namely epinephrine, have been known to exacerbate coronary vasospasm. (Click to enlarge.)
However, it was still patient-oriented, considering the patient’s clinical response, symptom resolution, and adverse events. Disease-Oriented Outcomes (DOOs) The PARAMEDIC-2 trial looked at the effectiveness of epinephrine in adult patients who suffered an out-of-hospital cardiac arrest. Schuh S, Freedman S, Coates A, et al.
While not specifically reviewed in this post, check out the methemoglobinemia tox card for more information about one of the other known events that can occur with local anesthetic administration. 1,2] Consider using a physiological marker to help identify inadvertent vascular injection, such as epinephrine. [3] BMJ Case Rep.
Dell KM, et al. Eisen S et al. Fielder AR, et al. Bm MV, et al. Toepfner N, et al. Toniutti M, et al. Meoli M, et al. Ashton JJ, et al. Ding G et al. Tanti DC, et al. Ahlqvist VH, et al. Chiang HL, et al. Wong J, et al. Fuller S et al. Koenis MM et al.
When simple maneuvers fail, we proceed to topical agents such as lidocaine with epinephrine, oxymetazoline, anterior nasal packing, and electrical or chemical cauterization. Paper: Zahed R, Moharamzadeh P, Alizadeharasi S et al. Adverse Effects: No serious adverse events were noted. Am J Emerg Med. 2013 Sep;31(9):1389-92.
Article: Abella BS et al. T5 (3.9%) patients with adverse events were reported in the IV Cetirizine group compared to 18 (3.9%) in the IV diphenhydramine group. Moreover, the FDA approved intravenous (IV) cetirizine to treat acute urticaria in 2019. Ann Emerg Med 2020. The mean time spent at a treatment center in hours was 1.7
After several cycles of defibrillation, epinephrine, and amiodarone, the patient remains in cardiac arrest. Current AHA guidelines do not recommend routine use of calcium in cardiac arrest (Panchal, et al., Calcium acts as a vasopressor and inotropic agent (Lindqwister, et al., He is found to be in ventricular fibrillation (VF).
Smith comment: In a large randomized trial of dopamine vs. norepinephrine (11) for shock which was published after the above-mentioned recommendations, dopamine had more adverse events (especially severe dysrhythmias, and especially atrial fibrillation). Taglieri N, Marzocchi A, Saia F, et al. Kosuge M, Ebina T, Hibi K, et al.
HIET improves contractility without increasing SVR, while vasopressin and epinephrine transiently increase SVR/MAP but worsen cardiac output in anesthetized dogs given propranolol (Holger 2007). References: Yuan TH, Kerns WP, Tomaszewski CA, et al. von Lewinski D, Bruns S, Walther S, et al. Disposition to ICU. Circulation.
Reference: Roberts et al. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Audrey’s academic interests include trauma and resuscitation.
Paper: Ibarra-Estrada, M et al. The study was too small to make strong conclusions about adverse events. References: Ibarra-Estrada, M et al. PMID: 36915146 [ Access on Read by QxMD ] Kirov MY et al. PMID: 11588440 Memis D et al. PMID: 12500513 Lopez A et al. Crit Care 2023. 95% CI 15.4 95% CI 15.4
1 The rationale for the shift away from normal saline in 2021 derived from multiple trials, including the Isotonic Solutions and Major Adverse Renal Events Trial (SMART) and Saline Against Lactated Ringer’s or Plasma-Lyte in the Emergency Department (SALT ED). References Evans L, Rhodes A, Alhazzani W, et al. units/minute.
And according to a paper from Russotto et al. titled “Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients from 29 Countries,” at least one major critical event occurred after intubation in 45.2% Of note, in the paper by Russotto et al., are at high risk.
Let me preface this by saying that these are my opinions which are based on my review of the medical literature and my real life experiences using mechanical CPR at the system level, including post-event analysis of resuscitations in which mechanical CPR was used. When this was first studied by Yost et al. Resuscitation. 2015;92:32–37.
He underwent CPR, and regained a pulse after epinephrine, with an organized narrow complex rhythm at 140, but still with severe shock. 3–8 Shi et al. Sandoval Y, Smith SW, Sexter A, et al. Shi S, Qin M, Shen B, et al. Guo T, Fan Y, Chen M, et al. Lala A, Johnson KW, Russak AJ, et al.
Article: Kumar M et al. It’s unclear whether interventions such as cauterization, clip placement, epinephrine injection, etc., References De Pietri L, Bianchini M, Montalti R, et al. PMID: 31229583 Kumar M, Ahmad J, Maiwall R, et al. PMID: 31148204 Rout G, Shalimar, Gunjan D, et al. Hepatology. 2020;71(1):235-246.
Nielsen N, Wetterslev J, Cronberg T et al. By the time of the study by Nielsen et al. The authors also investigated harms in both groups and determined no significant difference in adverse events between both groups. Kirkegaard H, Soreide E, de Haas, I et al. Kirkegaard et al. New Engl J Med. 2017;318(4):341–350.
IIa B In STEMI patients with stent implantation and an indication for oral anticoagulation, triple therapyd should be considered for 1–6 months (according to a balance between the estimated risk of recurrent coronary events and bleeding).
Rosh Review Website Link Further Reading Further FOAMed: [link] [link] References: Ahmad SA, Brito D, Khalid N, et al. doi:[link] Kosuge M, Ebina T, Hibi K, et al. Additional fluids will not improve her condition and may worsen it. Takotsubo Cardiomyopathy. Updated 2023 Jan 9]. In: StatPearls [Internet]. 2014;8:CMC.S14086.
Resuscitated with chest compressions, epinephrine. Here is the written paramedic report available after all the events were over: Patient was seen by witnesses to become unresponsive. including epinephrine, and there was ROSC. Mistaking such cases as an acute cardiac event is not uncommon because of these ECG changes.
Studies from the 1980s and 1990s found 5-14% of patients with hemoptysis had a life-threatening event (7,8). Bronchoscopy can be used for bleeding control with cold saline, epinephrine, activated factor VIIa, or TXA. Ittrich H, Bockhorn M, Klose H, et al. Mondoni M, Carlucci P, Job S, et al. Lee TW, Wan S, Choy DK, et al.
He was defibrillated twice and received two doses of epinephrine, with return of spontaneous circulation. A repeat ECG (see figure 3) was performed utilizing the technique described by Sangwatanaroj et al., References Sangwatanaroj S, Prechaway S, Sunsaneewitayakul B, et al. Antzelevitch C, Brugada P, Borggrefe M, et al.
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