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Date: October 28, 2024 Reference: Verma et al. Their hospital has struggled with a growing number of adverse events that often occur without warning. Reference: Verma et al. Clinical evaluation of a machine learning–based early warning system for patient deterioration.
Adverse events from nitrate administration during right ventricular myocardial infarction: a systematic review and meta-analysis. Adverse events from nitrate administration during right ventricular myocardial infarction: a systematic review and meta-analysis. Fanaroff et al looked at the ACC/AHA guidelines from 2008-2018 [4].
The biggest change has been the gradual replacement of diacetylmorphine (heroin) by fentanyl and other synthetic opioids. Along the same time, a veterinary sedative, xylazine , became popular in Puerto Rico in individuals who used injection drugs [3]. We treat with wound care and reserve surgical management only for limbs that are no longer viable.
Reference: Tjan et al. Conflicts in the ED often stem from clinical decision-making and actions, leading to potential adverse patient events and exacerbating access block issues. Reference: Tjan et al. Conflict in emergency medicine: A systematic review. These conflicts can ultimately lead to moral injury [1,2,3].
Major adverse cardiac events 40 minutes after giving the antiarrhythmic. Major adverse cardiac events 40 minutes after giving the antiarrhythmic. The following table shows their results, take a look: Note that procainamide leads with less adverse cardiac events. This was based on 11, thats not a typo, ELEVEN patients.
Pathophysiology Primary injury happens at the time of the traumatic event or shortly after in the high cervical to mid-thoracic spine. Tenenbein M, Macias CG, Sharieff GQ, et al, eds. Tenenbein M, Macias CG, Sharieff GQ, et al, eds. Refers to the Spinal Cord Function and Reflexes, not specifically hemodynamic issues.
What they did: Prospective randomized controlled trial, unblinded, multicenter study Conducted from January 2017 to December 2022 Patients with confirmed PSVT were randomly assigned to receive MVM, IV Adenosine, or combined therapy. This absence of detail leaves the study open to bias. Evidence suggests that a weight-based dosing approach (0.1
Date: July 21, 2023 Reference: Prekker et al. Date: July 21, 2023 Reference: Prekker et al. Intubation FPS is associated with fewer adverse events, most importantly hypoxia, hypotension, and cardiac arrest. Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults.
Studies such as those by Moise et al 14 and Ellis et al 39 have shown that the relative risk of developing an acute myocardial infarction in the territory supplied by an artery with a 70%. Furthermore, if this occurs at all, it is a rare event. years, with the interval as long as 12 or 18 years in some studies.
Date: October 2nd, 2019 Reference: Ramgopal et al. Changes in the Management of Children With Brief Resolved Unexplained Events (BRUEs). Date: October 2nd, 2019 Reference: Ramgopal et al. Changes in the Management of Children With Brief Resolved Unexplained Events (BRUEs).
Coming into triage, I see a young man—Georgian-speaking—bracing himself with a hand against the wall and holding his lower abdomen. With what I can only describe as a “grimace” by a singular word, his face conveyed so much more. Without talking or touching the patient, the triage nurse picked up on a deep pain.
Paper: Yerke JR et al. of cases) ≤24hrs vs >24hrs Infusion Duration: 3.8hrs vs 42.4hrs Max Dose: 10mcg/min vs 10mcg/min Extravasation Events: 24 (4.7%) vs 11 (8.7%) Extravasation incidence/1000d of Peripheral Infusion: 176.4 No Extravasation Event vs Extravasation Event Age: 63 vs 67 years BMI: 28.3 CHEST 2024.
[display_podcast] Date: May 16, 2018 Reference: Freund et al. Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial. display_podcast] Date: May 16, 2018 Reference: Freund et al. Reference: Freund et al.
References von Hellmann R, Fuhr N, et al. Koh LK, Kong CE, et al. A study in the February issue of Annals conducted a meta-analysis of 18 studies and concluded that bougie use was associated with increased first-attempt intubation success. Some important limitations of this analysis should be recognized. Ann Emerg Med.2024;83(2):132-144.
Common inciting events include viral infections, autoimmune diseases, or immunodeficiency syndromes [1]. Provan D, Arnold DM, Bussel JB, et al. On the day of presentation, she developed a painful, intermittently bleeding “blood blister” to the left lower cheek that had increased in size, as well as new red spots on her arms and legs.
Reference: Friedman et al. Reference: Friedman et al. million visits each year in the USA ( Friedman et al Spine 2010 ). However, their use is associated with increased adverse events. These include: acetaminophen ( Williams et al Lancet 2014), muscle relaxants ( Friedman et al JAMA 2015), NSAIDs ( Machado et al
Reference: Warren et al. Reference: Warren et al. The conclusion from Berman et al was to recommend antacid monotherapy (5). Reference: Warren et al. Date: September 22nd, 2020 Guest Skeptic: Dr. Chris Bond is an emergency medicine physician in Calgary. A randomized double-blind clinical trial. AEM Sept 2020.
[display_podcast] Date: January 15th, 2018 Reference: Sadeghirad B, et al. display_podcast] Date: January 15th, 2018 Reference: Sadeghirad B, et al. Reference: Sadeghirad B, et al. Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Date: October 27th, 2022 Reference: Hayashi et al. Date: October 27th, 2022 Reference: Hayashi et al. Although minor adverse events, such as brief apnea or hypoxia, are common, significant adverse events are very rare, and the benefits are clear (Bellolio 2016).
Date: March 31st, 2022 Reference: Butt et al. Date: March 31st, 2022 Reference: Butt et al. Children represent one group of patients that are less likely to receive adequate analgesia ( Brown et al , Selbst and Clark ). Reference: Butt et al.
[display_podcast] Date: January 9th, 2018 Reference: Soleimanpour H et al. display_podcast] Date: January 9th, 2018 Reference: Soleimanpour H et al. A study from Bindman et al. Effectiveness of intravenous lidocaine versus intravenous morphine for patients with renal colic in the emergency department.
Date: June 12th, 2022 Reference: Finfer et al. Date: June 12th, 2022 Reference: Finfer et al. Two large, cluster-randomized trials ( SMART and SALT-ED ) showed a small benefit to the use of balanced crystalloids in preventing a composite outcome of Major Adverse Kidney Events within 30 days (aka MAKE-30).
[display_podcast] Date: August 22nd, 2018 Reference: Riskin A, Erez A, Foulk TA, et al. display_podcast] Date: August 22nd, 2018 Reference: Riskin A, Erez A, Foulk TA, et al. Reference: Riskin A, Erez A, Foulk TA, et al. Rudeness and Medical Team Performance. Pediatrics. Rudeness and Medical Team Performance. Pediatrics.
Date: June 30th, 2022 Reference: McGinnis et al. Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter? Date: June 30th, 2022 Reference: McGinnis et al. Major adverse cardiac event rates in moderate-risk patients: Does prior coronary disease matter? Reference: McGinnis et al.
Myth #1: Musculoskeletal Adverse Events (MAE) This concern is likely the most common reason fluoroquinolones are rarely used in children. Musculoskeletal Adverse Events include: Articular cartilage damage causing arthralgias or arthritis , Tendonitis , and Tendon rupture. Which is a risk of 1 event for 62.5
Patients with DRESS syndrome are at risk of developing systemic autoimmune sequelae, which can appear anywhere from months to 4 years after the initial event [1]. PMID: 37082745 Sasidharanpillai S, Ajithkumar K, Jishna P, et al. [1-3] Cutaneous manifestations typically consist of an urticarial, maculopapular eruption.
EBM Update: ANNEXA-1 and DOAC Reversal in ICH Article: Connolly SJ, Sharma M, Cohen AT, et al; ANNEXA-I Investigators. Increased thrombotic events with Andexanet alpha. Secondary outcome: determine which of the two reverting strategies is less affected by thromboembolic events. N Engl J Med. 2024 May 16;390(19):1745-1755.
A systematic review examined 69 articles (mostly cohort studies and clinical trials) looking at the common adverse events (not just PRIS) following the use of propofol in children and neonates. Mortality associated with PRIS has been estimated to be around 33% and becomes even higher if the diagnosis is delayed. References Bray RJ.
GLP-1 agonists are also associated with improved ejection fraction, coronary blood flow, and cardiac output while reducing the risk of cardiovascular events, infarction size, and all-cause mortality. Adverse events are common in those using GLP-1 agonists, but the vast majority of these are minor. Take for example semaglutide.
Paper: Singer S, et al. Prior literature primarily focused on safety and medication errors, and while this study did the same, they also assessed variables associated with PDP response. The safety and efficacy of push dose vasopressors in critically ill adults. Am J Emerg Med. 2022 Sep 5.
Higher rates of adverse events have not been seen in Emergency Departments where the use of imaging is lower. Each article will take a deeper dive into each recommendation’s supporting evidence and practical implications. Do not obtain radiographs in children with bronchiolitis , croup, asthma, or first-time wheezing.
EMRAP HD: Epistaxis Posterior Pack References Cassisi NJ et al. PMID: 5569677 Zeyyan E et al. Take Home Points: Posterior epistaxis is a rare, life-threatning presentation. The key is in identifying and rapidly gaining control with a posterior pack or foley catheter. Laryngoscope 1971; 81(8): 1261-6.
12 Weight gain (up to 70%), development of cataracts (up to 15%), fractures (up to 12%), and neuropsychiatric events (up to 10%) are the most common adverse events. 12 Weight gain (up to 70%), development of cataracts (up to 15%), fractures (up to 12%), and neuropsychiatric events (up to 10%) are the most common adverse events.
The authors found that the 1 year rate of major adverse cardiovascular events (MACE) was 15.5%. We always work hard, but we may not have time to read through a bunch of journals. It’s time to learn smarter. Originally published at JournalFeed , a site that provides daily or weekly literature updates. West J Emerg Med. 2024;25(5):680-689. #3:
Cuffed Endotracheal Tubes show no difference in immediate post-extubation adverse events (i.e On this 10 year anniversary, we chose to throw this one back in the oven to include some even more delicious data on cuffed endotracheal tube (ETT) use. In a systematic review of 10 RCTs comparing cuffed vs. uncuffed ETTs. 1.70) and 0.78 (0.46–1.35),
Beats 9-12 : Continuation of the previously described events, all inducible by the pause (and thus, prolongation of refractoriness) created by the PVC of Beat 8. A 12 Lead ECG was recorded secondary to bizarre telemetry findings at bedside. Said differently, it’s a mess. The reason for this is Phase III block. slowing of the heart rate).
Some refer to an ischemic event in this territory with clinical findings as posterior inferior cerebellar artery syndrome. Central causes of vertigo include ischemic stroke, demyelinating conditions, cerebellar hemorrhage, vertebrobasilar insufficiency, vertebral artery dissection, multiple sclerosis, malignancy, and vestibular migraine.
Because EGAs do not isolate the trachea as the ETT does, the risk of aspiration events increases, and due to the blind placement of many of these devices, unidentified airway occlusion can occur. Benger JR, Kirby K, Black S, et al. Wang HE, Schmicker RH, Daya MR, et al. Ramaiah R, Das D, Bhananker SM, et al. 3rd Edition.
of people who take NSAIDs ( Nzeako 2010 ). patients that take ACE inhibitors (but 20-30% of all angioedema presentations to the Emergency Department) 3 times more common in Black Americans ( Kostis 2005 ) 0.01 of people who take NSAIDs ( Nzeako 2010 ). Typically involves the mouth, larynx, pharynx, and subglottic tissue ( Kostis 2005 ).
PMID 7073040 Moore TJ, Walsh CS, Cohen MR. Reported adverse event cases of methemoglobinemia associated with benzocaine products. Nelson, et al., Nelson, et al., Background Methemoglobinemia is a disorder of hemoglobin in which the iron atom has been oxidized from the normal Fe 2+ to Fe 3+. Methemoglobinemia. Ann Emerg Med.
In order to avoid connectivity issues with Wifi, the event administrators broadcasted from an ethernet-connected computer. Originally developed by Marsh et al., Deploying our security teams, a robust registration system, and the waiting room function in Zoom were important strategies for avoiding disturbances to the event.
The seven studies in children included a meta-analysis of four studies, which included 388 children and demonstrated a pooled incidence of adverse events of 3.3%. Shock is defined as a type of circulatory failure where lack of oxygen leads to dysfunction of vital organs. This is beyond the scope of this blog post.
Severe TBI is broadly defined as a Glasgow Coma Score (GCS) of less than 8 following a traumatic event. Kochanek et al… Kochanek PM, Tasker RC, Carney N, Totten AM, Adelson PD, Selden NR, et al. There was also a meta-analysis on this topic in the adult population by Schwimmbeck et al [6] in 2021.
Attention was turned to the consideration of severe coronary vasospasm as the inciting event for cardiopulmonary arrest and the nidus for refractory ventricular fibrillation. References Prinzmetal M, Kennamer R, Merliss R, et al. Myerburg RJ, Kessler KM, Mallon SM et al. Magid DJ, Aziz K, Cheng A, et al. Angina pectoris.
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