ALiEM

OCTOBER 30, 2024

Clinical impact: Rather than arguing with the patient about the likelihood of this phenomenon occurring and whether this is a true allergy, the patient is informed that they do not need to immediately start treatment to receive care in the hospital. Multimodal medication options for fentanyl-xylazine withdrawal management in London et al.

E-9-1-1 161

E-9-1-1 Naloxone Emergency Department ALS 161

ALiEM

NOVEMBER 29, 2023

Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome. In patients with minimal response to naloxone, xylazine toxicity may be suspected [10]. PMID: 34529640 Ayub S, Parnia S, Poddar K, et al. MMWR Morb Mortal Wkly Rep.

Naloxone 169

Naloxone Overdose Epinephrine ALS 169

REBEL EM

JUNE 5, 2023

Background Information: Opioid overdose deaths have been increasing in the past twenty years. Clinical Question: Is low-dose take-home packages of buprenorphine/naloxone in the ED feasible compared to standard dose buprenorphine/naloxone? mg–naloxone 0.125 mg SL BID One-quarter tablet 2 Buprenorphine 1 mg–naloxone 0.25

Naloxone 97

Naloxone ED Overdose Emergency Department 97

ACEP Now

OCTOBER 15, 2023

After enrollment, patients were randomized either to a modified-release oxycodone-naloxone combination opiate, starting with an initial dose containing 5 mg of oxycodone, or placebo. The addition of naloxone to the tablets may also provide a confounder in terms of the analgesia provided. Jones CMP, Day RO, Koes BW, et al.

Emergency Department 52

Emergency Department Naloxone ALS OR 52

EMDocs

JANUARY 22, 2025

In the field, he was given 4 mg intranasal (IN) naloxone and rescue breaths via bag valve mask. He is administered 2mg intravenous (IV) naloxone and shortly after develops precipitated withdrawal with altered mental status, diaphoresis, vomiting, and diarrhea. When should a naloxone infusion be considered?

Naloxone 96

Naloxone E-9-1-1 Overdose NARCAN 96

ALiEM

JANUARY 6, 2025

Necrotizing fasciitis Case Question: Will naloxone reverse a xylazine overdose? References Papudesi, Bhavani Nagendra, et al. Author information Rebecca Fenderson, MD Emergency Medicine Resident Cooper University Hospital | The post SAEM Clinical Images Series: Xylazine Wounds appeared first on ALiEM. BMP : Na 126; K+ 5.9;

NARCAN 141

NARCAN Overdose Naloxone Emergency Department 141

Don't Forget the Bubbles

JULY 5, 2023

Naloxone (opioid antidote) should be available in ED in case of severe respiratory depression. Macharia AW et al. Sinkin JC, Wood BC, Sauerhammer TM, et al. Ware et al. It has many useful videos for patients and doctors about sickle cell disease, management and communication scenarios. A newer therapy option is ketamine.

E-9-1-1 126

E-9-1-1 ACS OR ICU 126