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ACMT Toxicology Visual Pearl: Needle to Necrosis

ALiEM

Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome. In patients with minimal response to naloxone, xylazine toxicity may be suspected [10]. PMID: 34529640 Ayub S, Parnia S, Poddar K, et al. MMWR Morb Mortal Wkly Rep.

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SGEM#241: Wake Me Up Before You Go, Go – Using the HOUR Rule

The Skeptics' Guide to EM

Date: January 17th , 2019 Reference: Clemency et al. Hospital Observation Upon Reversal (HOUR) With Naloxone: A Prospective Clinical Prediction Rule Validation Study. Date: January 17th , 2019 Reference: Clemency et al. Sixty minutes after receiving naloxone he is GCS 15 and walking to the desk demanding to be discharged.

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professionals

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REBEL Cast Ep117: Low Dose vs Standard Dose Take-Home Buprenorphine From the ED

REBEL EM

This study investigated whether it is feasible to initiate buprenorphine/naloxone in the form of “take home” packages containing low-dose and standard-dose inductions. REBEL Cast Ep117: Low-Dose vs Standard-Dose Take Home Buprenorphine From the ED Click here for Direct Download of the Podcast Paper: Moe et. PMID 33392580.

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2023 AHA Update on Management Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning

EMDocs

Naloxone administration may reverse respiratory arrest, preventing progression to cardiac arrest. Editorial Comment: Naloxone first, flumazenil only for pure benzo’s (e.g., Editorial Comment : Use standard BLS/ALS measures, especially if in cardiac arrest. COR No Benefit, LOE C-EO. COR Harm, LOE B-R. if used for sedation).

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SGEM#374: Bad Habits – Medications for Opioid Use Disorder in the Emergency Department

The Skeptics' Guide to EM

Date: August 23rd, 2022 Reference: Schoenfeld et al. Date: August 23rd, 2022 Reference: Schoenfeld et al. He is successfully resuscitated using naloxone and is stable after an observation period. Reference: Schoenfeld et al. He is also an avid FOAM supporter/producer through various online outlets including TheSGEM.

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Suicide Attempt in the Terminally Ill Cancer Patient with Advance Directive

ACEP Now

Though paramedics administered naloxone, he remained somnolent. You ultimately begin a slow naloxone infusion and admit him to the medical ICU. You question yourself for ordering IV potassium and starting a naloxone infusion, knowing you are causing discomfort for the patient who has known significant cancer-related pain.

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Xylazine: “Zombie Drug” is an Emerging Threat

ACEP Now

While naloxone can treat fentanyl overdose, overdose symptoms may persist when xylazine is involved. References Friedman J, et al. Alexander RS, et al. Love JS, et al. Reyes JC, et al. Ruiz-Colón K, et al. Capraro AJ, et al. Rodríguez N, et al. Malayala SV, et al. 2022;233:109380.