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SGEM#453: I Can’t Go For That – No, No Narcan for Out-of-Hospital Cardiac Arrests

The Skeptics' Guide to EM

Date: September 18, 2024 Reference: Dillon et al. Naloxone and Patient Outcomes in Out-of-Hospital Cardiac Arrests in California. Your partner asks if you want to administer naloxone as well. Today’s study looks at the role of naloxone in OHCA. JAMA Network Open.

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SGEM#179: Chase the Dragon and Naloxone

The Skeptics' Guide to EM

[display_podcast] Date: May 19th, 2017 Reference: Willman et al. Do heroin overdose patients require observation after receiving naloxone? display_podcast] Date: May 19th, 2017 Reference: Willman et al. Do heroin overdose patients require observation after receiving naloxone? Clinical Toxicology 2017.

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professionals

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Tranq dope (fentanyl-xylazine combination): A new horizon in opioid withdrawal treatment

ALiEM

Alternatively, one can cut the 2 mg Suboxone (buprenorphine + naloxone combination) strips into 4 pieces after waiting for a longer washout period (72-96 hours of abstinence from non-medical opioids) before starting the induction. Multimodal medication options for fentanyl-xylazine withdrawal management in London et al.

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ACMT Toxicology Visual Pearl: Needle to Necrosis

ALiEM

Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome. In patients with minimal response to naloxone, xylazine toxicity may be suspected [10]. PMID: 34529640 Ayub S, Parnia S, Poddar K, et al. MMWR Morb Mortal Wkly Rep.

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SGEM#241: Wake Me Up Before You Go, Go – Using the HOUR Rule

The Skeptics' Guide to EM

Date: January 17th , 2019 Reference: Clemency et al. Hospital Observation Upon Reversal (HOUR) With Naloxone: A Prospective Clinical Prediction Rule Validation Study. Date: January 17th , 2019 Reference: Clemency et al. Sixty minutes after receiving naloxone he is GCS 15 and walking to the desk demanding to be discharged.

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2023 AHA Update on Management Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning

EMDocs

Naloxone administration may reverse respiratory arrest, preventing progression to cardiac arrest. Editorial Comment: Naloxone first, flumazenil only for pure benzo’s (e.g., Editorial Comment : Use standard BLS/ALS measures, especially if in cardiac arrest. COR No Benefit, LOE C-EO. COR Harm, LOE B-R. if used for sedation).

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REBEL Cast Ep117: Low Dose vs Standard Dose Take-Home Buprenorphine From the ED

REBEL EM

This study investigated whether it is feasible to initiate buprenorphine/naloxone in the form of “take home” packages containing low-dose and standard-dose inductions. REBEL Cast Ep117: Low-Dose vs Standard-Dose Take Home Buprenorphine From the ED Click here for Direct Download of the Podcast Paper: Moe et. PMID 33392580.