ALiEM

NOVEMBER 29, 2023

Recently, xylazine has gained attention in the media with increasing reports of xylazine-related overdose deaths in patients. When combined with illicit opioids such as heroin and fentanyl, xylazine may increase the risk of fatal overdose given the augmented sedation and respiratory depression effects [2]. MMWR Morb Mortal Wkly Rep.

Naloxone 169

Naloxone Overdose ALS Epinephrine 169

The Skeptics' Guide to EM

JANUARY 19, 2019

Date: January 17th , 2019 Reference: Clemency et al. Hospital Observation Upon Reversal (HOUR) With Naloxone: A Prospective Clinical Prediction Rule Validation Study. Date: January 17th , 2019 Reference: Clemency et al. The EMS crew observes drug paraphernalia and suspect an intravenous (IV) opioid overdose.

Naloxone 130

Naloxone Overdose Emergency Medical Services Emergency Department 130

REBEL EM

JUNE 5, 2023

Background Information: Opioid overdose deaths have been increasing in the past twenty years. The national number of overdose deaths from any opioid has increased 62.5% In addition, buprenorphine has a lower risk of death from overdose when compared to methadone (2). PMID 33392580.

Naloxone 95

Naloxone ED Overdose Emergency Department 95

The Skeptics' Guide to EM

AUGUST 27, 2022

Date: August 23rd, 2022 Reference: Schoenfeld et al. Date: August 23rd, 2022 Reference: Schoenfeld et al. Case: A 24-year-old male presents to the emergency department (ED) after a fentanyl overdose. He is successfully resuscitated using naloxone and is stable after an observation period. Reference: Schoenfeld et al.

Emergency Department 100

Emergency Department Naloxone Overdose ED 100

EMDocs

NOVEMBER 6, 2023

Opioid overdose remains the leading cause of cardiac arrest due to poisoning in North America. Naloxone administration may reverse respiratory arrest, preventing progression to cardiac arrest. Editorial Comment: Naloxone first, flumazenil only for pure benzo’s (e.g., COR No Benefit, LOE C-EO. COR Harm, LOE B-R.

Naloxone 94

Naloxone OR Overdose BLS 94

ACEP Now

JULY 7, 2023

Xylazine is a veterinary sedative that has been increasingly implicated in overdose deaths throughout the United States. percent of all overdose deaths in 2020. 1 Known by street names such as “tranq,” “tranq-dope,” or “zombie drug,” xylazine is increasingly found in patients with opioid overdose. References Friedman J, et al.

Overdose 98

Overdose ALS Naloxone Emergency Department 98

ACEP Now

JULY 7, 2023

Patients with opiate overdose get naloxone. References American College of Emergency Physicians Clinical Policies Subcommittee on the Adult Psychiatric P, Nazarian DJ, Broder JS, et al. Currier GW, Chou JC, Feifel D, et al. Zaman H, Sampson SJ, Beck AL, et al. Patients with sepsis get antibiotics.

Emergency Department 52

Emergency Department ED ALS Naloxone 52