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In contrast, protamine could be used for heparin and LMWH reversal and vitamin K, fresh frozenplasma and prothrombinase complex concentrate could be used to reverse coumadin ( Hunt and Levi BMJ 2018 ). This changed in 2015 when the Food and Drug Administration (FDA) approved idarucizumab for the reversal of dabigatran.
Fresh frozenplasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.”
Surprisingly, there are different definitions of paediatric major haemorrhage, with no single agreed-upon definition. Many of these definitions are not useful in acutely bleeding children as they require measuring the amount of blood that was lost or transfused over prolonged periods. What is major haemorrhage?
Figure 1: The Young-Burgess classification of pelvic ring fractures (source: [link] 3 It is paramount to differentiate the definitions of “hemodynamically unstable” and “mechanically unstable” pelvic fractures. For a broader overview of pelvic trauma, please review Dr. Lupez’s 2017 article here: [link].
Cholera Case Definitions and Diagnosis.; Severe malaria management. 84 Adapted from: World Health Organization (WHO). WHO Guidelines for Malaria.; Accessed June 11, 2023. 2020;38:A73-A82. doi:10.1016/j.vaccine.2019.07.099 2019.07.099 Centers for Disease Control and Prevention (U.S.). Zinc Treatment. Published online November 14, 2022.
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