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In contrast, protamine could be used for heparin and LMWH reversal and vitamin K, fresh frozenplasma and prothrombinase complex concentrate could be used to reverse coumadin ( Hunt and Levi BMJ 2018 ). Idarucizumab clearly and effectively removes dabigatran from circulation and this ought to be occasionally clinically useful.
Fresh frozenplasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.”
Surprisingly, there are different definitions of paediatric major haemorrhage, with no single agreed-upon definition. Many of these definitions are not useful in acutely bleeding children as they require measuring the amount of blood that was lost or transfused over prolonged periods. What is major haemorrhage?
Figure 1: The Young-Burgess classification of pelvic ring fractures (source: [link] 3 It is paramount to differentiate the definitions of “hemodynamically unstable” and “mechanically unstable” pelvic fractures. Introduction The pelvic ring is made up of the bony ilium, ischium, pubis, and sacrum, which are held together with ligaments.
History of Present Illness The collateral history indicates that her symptoms began one week into her journey, but medical care was inaccessible at the time. The family reports no history of food allergies, insect bites, or contact with sick individuals. The patient did not receive pre-travel prophylaxis for malaria, hepatitis A, or yellow fever.
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