EMDocs

APRIL 10, 2024

1-5] Since then, many more medications have been developed and deployed. Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2]

E-9-1-1 111

E-9-1-1 Plasma Epinephrine Life Support 111

EMDocs

SEPTEMBER 7, 2023

1 Clinical Questions: When should a clinician suspect diethylene glycol (DEG) toxicity? DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. Elimination half-life data is not well established but increases in larger overdoses and as renal injury begins to occur.

E-9-1-1 92

E-9-1-1 ALS Plasma Emergency Department 92

EMDocs

JANUARY 22, 2025

Background: Fentanyl has contributed to a significant increase in drug overdose deaths in recent years. 1 Most heroin in the United States actually contains fentanyl and fentanyl analogs. Naloxone reverses the analgesic, respiratory, sedative , and miotic e ffects of opioids. 6 Image 1: Structure of naloxone.

Naloxone 96

Naloxone E-9-1-1 Overdose NARCAN 96

EMDocs

DECEMBER 6, 2024

Historically, iron toxicity and exposure affected children in unintentional overdose disproportionately. 1 The incidence of iron overdose and iron ingestion related deaths has significantly decreased over time, likely attributable to federal regulation. 1 Table 1: Iron content of various preparations.

E-9-1-1 97

E-9-1-1 Frozen Plasma Plasma Overdose 97