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Naloxone and Patient Outcomes in Out-of-Hospital Cardiac Arrests in California. He currently practices emergency medicine in New Mexico in the ED, in the field with EMS and with the UNM Lifeguard Air Emergency Services. Your partner asks if you want to administer naloxone as well. JAMA Network Open.
Xylazine is an alpha-2 agonist similar to clonidine that inhibits the release of norepinephrine and epinephrine resulting in decreased vascular tone and heart rate [4]. Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome.
In the field, he was given 4 mg intranasal (IN) naloxone and rescue breaths via bag valve mask. In the ED, he develops recurrent respiratory depression and hypoxia to 80%. He is administered 2mg intravenous (IV) naloxone and shortly after develops precipitated withdrawal with altered mental status, diaphoresis, vomiting, and diarrhea.
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