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These medications are a vital tool in the care of ED patients, from simple local analgesia for a laceration repair to regional analgesia for painful procedures. Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] Poisoning & Drug Overdose.
DEG is rapidly absorbed when ingested and can reach peak plasma and brain tissue concentrations within four hours of ingestion. Elimination half-life data is not well established but increases in larger overdoses and as renal injury begins to occur. “Fomepizole” in Goldfrank’s Toxicologic Emergencies , 11e Eds.
This is pathognomonic of hyperkalemia (I suppose it could be due to a massive overdose of a sodium channel blocking drug, maybe). They transported to the ED. The history, obtained subsequently, is interesting: The patient had been seen at an outside ED 2 days prior and the K was 2.5 She was in shock with thready pulses.
In the ED, he develops recurrent respiratory depression and hypoxia to 80%. Background: Fentanyl has contributed to a significant increase in drug overdose deaths in recent years. How long should they stay in the ED? Clinical Pearls: Naloxone is lifesaving in opioid overdoses. The answer is, its complicated.
A 33-year-old male with a history of drug use presented to the emergency department (ED) for extreme agitation after receiving two doses of 2 mg naloxone by EMS for respiratory depression. He was admitted for a suspected kratom overdose and acute kratom withdrawal. Todd DA, Kellogg JJ, Wallace ED, et al. Clin Toxicol (Phila).
On arrival to the ED the patient’s initial vital signs are temperature 38.5C, BP 102/48, HR 106, RR 20. Historically, iron toxicity and exposure affected children in unintentional overdose disproportionately. Coagulopathy: Parenteral vitamin K and/or fresh frozen plasma (FFP) as clinically indicated. 2 L/hr in adults.
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