ACMT Toxicology Visual Pearl: Needle to Necrosis
ALiEM
NOVEMBER 29, 2023
Xylazine is an alpha-2 agonist similar to clonidine that inhibits the release of norepinephrine and epinephrine resulting in decreased vascular tone and heart rate [4]. Naloxone will not reverse the effects of xylazine; however, it is routinely given in unresponsive or obtunded patients presenting with an opioid toxidrome.
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