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A 33-year-old male with a history of drug use presented to the emergencydepartment (ED) for extreme agitation after receiving two doses of 2 mg naloxone by EMS for respiratory depression. Upon arrival, his vitals were as follows: heart rate of 132 bpm, respiratory rate of 27, blood pressure of 134/75 mm Hg, and a SpO 2 of 100 percent.
Is there an ideal observation period in the emergencydepartment after reversal with naloxone? Profound increase in epinephrine concentration in plasma and cardiovascular stimulation after mu-opioid receptor blockade in opioid-addicted patients during barbiturate-induced anesthesia for acute detoxification. Ann Emerg Med.
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