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REBEL Core Cast 108.0 – Angioedema

REBEL EM

Bradykinin Mediated Plasma globulins called kininogens release bradykinin and cause vascular permeability. Image: ( Morgan 2010 ) Features Absence of urticaria and pruritus Insidious onset (24-36 hours) ACE Inhibitors Inhibition of ACE hinders the degradation of bradykinin and can lead to idiosyncratic angioedema.

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ToxCard: Local Anesthetic Systemic Toxicity

EMDocs

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] If epinephrine is used, small initial doses ( <1 ug/kg) are preferred.

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Transfusion Reactions

Core EM

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

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SPECIAL EPISODE-RECAP of the EMS/MD1 Fellowship Conference!

The Overrun Podcast

Qasim is on Twitter at: @emeddoc Dr. Callelo: @DrDianeC, @njpoisoncenter, also at @ToxAndHound The COMBAT trial for prehospital plasma: [link] The PAMPHER trial: [link] BOKUTOH criteria study: [link] PARAMEDIC2 study of Epinephrine in OHCA: [link] Pediatric airway management in cardiac arrest: [link] Heads up CPR in OHCA: [link] And, why it may NOT (..)

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Transfusion Reactions

Core EM

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

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STEMI with Life-Threatening Hypokalemia and Incessant Torsades de Pointes

Dr. Smith's ECG Blog

Internal potassium balance and the control of the plasma potassium concentration. Volume 34 , Issue 11 , pages 10771082 , November 1994 Although concentrated infusions of potassium chloride commonly are used to treat hypokalemia in intensive care unit patients, few studies have examined their effects on plasma potassium levels.

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Spicy Bites - Snake Envenomation

FOAMfrat

Along with inducing coagulopathy, venom toxins may contribute to local and/or systemic hemorrhage and plasma extravasation by means of basement membrane degradation within the vasculature. These side effects do not contraindicate antivenom administration and can be treated with antihistamines and epinephrine.