EMDocs

APRIL 10, 2024

Metabolism of ester anesthetics is by plasma cholinesterase, whereas amides are metabolized by the cytochrome P450 system in the liver. [6] 6] Action of local anesthetics is dependent upon the molecule crossing the plasma membrane in a unionized form. [2] 2] This linking group can be either an amide (e.g., lidocaine) or an ester (e.g.,

E-9-1-1 111

E-9-1-1 Plasma Epinephrine Life Support 111

Critical Care Scenarios

OCTOBER 31, 2021

Diurese until you develop flow problems (suction events) on the pump, a useful indicator of low intravascular volume.* Plasma free hemoglobin levels may be a useful marker that changing your oxygenator could improve gas exchange.* Inhaled vasodilators can be continued or weaned depending on right heart function.

Interfacility Transport 100

Interfacility Transport Plasma ICU EMS 100

AAEM RSA

APRIL 1, 2021

2,3 Here we examine some of the evidence behind the various components of MTPs, specifically calcium and factor VIIa, and the ratios in which the main products of red blood cells, plasma, and platelets should be administered. What is the ideal blood component ratio for massive transfusion in traumatic hemorrhage? 248(3):447-58.

E-9-1-1 52

E-9-1-1 Plasma ACS ALS 52

EMDocs

NOVEMBER 20, 2023

For patients on VKAs to prevent stroke in nonvalvular atrial fibrillation who require reversal, 4-factor prothrombin complex concentrate (PCC) is preferred to fresh frozen plasma (FFP) because of the rapidity of INR reduction (Conditional recommendation, very low-quality evidence). Conditional recommendation, low-quality evidence).

Frozen Plasma 104

Frozen Plasma FFP Plasma OR 104

Core EM

OCTOBER 2, 2024

Author: Natalie Bertrand, MD Editor: Naillid Felipe, MD Background: Definition: adverse reaction to blood product administration Incidence: more common in children than adults, except for delayed hemolytic transfusion reactions Allergic (non-anaphylaxis) – Platelets 1-3%; RBCs 0.1-0.3% mg IF requiring IM Epi >3x, switch to IV Epi, 0.05-0.1

Allergic Reaction 100

Allergic Reaction Plasma ED Epinephrine 100

EMDocs

JULY 13, 2024

Therefore, these antibiotics would not be appropriate in the event that the patient had pelvic inflammatory disease or endometritis secondary to chlamydia or gonorrhea. Plasma cell endometritis is associated with Chlamydia trachomatis infection. However, this patient has a history more concerning for postpartum endometritis.

EMS 91

EMS E-9-1-1 Plasma OR 91

Don't Forget the Bubbles

AUGUST 2, 2023

Pro-inflammatory states may also play a role, as patients with CRPS have significantly higher levels of plasma cytokines and chemokines. We know that fractures are the precipitating event in about 5–14% of cases and surgical procedures in 10–15%. Stress has also been shown to play an important role in inducing and perpetuating CRPS.

MPD 98

MPD ALS Plasma OR 98

Emergency Medicine Ireland

OCTOBER 28, 2020

Treatment consists of: * PLEX – actual proper PLEX with plasma replacement as opposed to just washing out all the good stuff and giving albumin as replacement. The plasma replacement replaces factors and reduces the bleeding risk (which is already high) but also acts as a source of ADAMSTS13.

Critical Care 40

Critical Care Plasma FFP ICU 40

Dr. Smith's ECG Blog

JULY 27, 2023

Under most circumstances — this combination of ECG findings would point to an acute event. Peak plasma concentration of amphetamines is rapid ( within minutes ) following inhalation or injection. But — the sum of this initial ECG is more than each of its parts.

Coronary 52

Coronary ACS Naloxone Plasma 52

REBEL EM

NOVEMBER 28, 2022

Xian 2019) 4-Factor Prothrombin Complex Concentrates (4F-PCC), or K-Centra, is a derivative of human plasma and is explicitly used to reverse vitamin K antagonists such as warfarin and non-specifically in the reversal of DOACs. 30-day all-cause mortality Secondary: Thromboembolic events within the first 5 days of 4F-PCC or AA administration.

OR 52

OR Plasma ALS EMS 52

FOAMfrat

AUGUST 15, 2024

Moreover, LTOWB also allows us to administer platelets and plasma, in addition to red cells, to promote clotting and homeostasis. If you don't have access to LTOWB and are administering component therapies such as PRBCs or plasma, this is still incredible and I highly encourage it! Like I said, some blood is better than no blood!

Plasma 69

Plasma Ambulance ALS Emergency Department 69

ACEP Now

NOVEMBER 16, 2023

Fresh frozen plasma, or FFP, should only be given to cirrhotic patients as part of the massive transfusion protocol in cases of profound hypotension, as “patients with cirrhosis rarely have true enzymatic hypocoagulability, and FFP may worsen bleeding due to over-resuscitation and dilution of coagulation factors.” 6 Balloon tamponade (i.e.,

Frozen Plasma 52

Frozen Plasma FFP ALS Plasma 52

Dr. Smith's ECG Blog

FEBRUARY 18, 2022

In fact, there is laboratory evidence that CO toxicity increases Plateletneutrophil aggregates and plasma myeloperoxidase (MPO) concentration and thus may precipitate ACS (though this is by no means clinically proven). Intravascular Neutrophil Activation Due to Carbon Monoxide Poisoning What do you think of this ECG?

ACS 52

ACS Plasma OR STEMI 52

ACEP Now

FEBRUARY 11, 2024

One side effect of this medication is that it can reduce the absorption of antiepileptic medications such as valproate, vigabatrin, and lamotrigine and reduce their plasma concentration, thus putting patients taking these medications at higher risk of seizure. A prescription for achieving equitable access to antiobesity medications.

Overdose 52

Overdose ACS Plasma ALS 52

Don't Forget the Bubbles

MAY 15, 2023

This response varies between individuals, age groups and developmental stages, so a single plasma concentration cannot be defined. If there is clinical concern for hypoglycaemia, plasma glucose concentration should be measured. Learning point: Take a plasma glucose sample and ask the lab to run it urgently – time is sugar!

ED 103

ED Plasma OR ALS 103

EMDocs

DECEMBER 18, 2023

The first was the suggestion to use balanced crystalloid fluids, such as lactated ringers or plasma-lyte, instead of normal saline. This is primarily a result of increased vascular permeability and decreased vascular tone, leading to vasodilation. 15 Two changes were elucidated in the 2021 SSC guidelines for fluid resuscitation.

E-9-1-1 93

E-9-1-1 ALS Emergency Department Plasma 93

EMDocs

JUNE 3, 2023

Institutional protocols should be utilized, keeping in mind that either whole blood or a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma are optimal. 13 Massive transfusion protocols (MTP) are hallmarks of trauma resuscitation, and they are critical to the unstable pelvic fracture patient. 2021;52(10):2697-2701.

ED 66

ED Operating Room ALS Frozen Plasma 66

Don't Forget the Bubbles

JULY 5, 2023

SCD, therefore, is not only a mechanical disease but there are also many other cellular and plasma factors as well as endothelial interaction that generate chronic inflammation. Acute management: Urgent imaging with CT scan and/or MRI/MRA to define the event and exclude a haemorrhagic component.

E-9-1-1 126

E-9-1-1 ACS OR ICU 126

American Burn Association

MARCH 26, 2025

The event will bring together burn care professionals from around the globe to share cutting-edge research, clinical practices, and innovations in burn care. Does Adding Fresh Frozen Plasma to Burn Resuscitation Improve Outcomes in Thermal Injury?; Testosterone Therapy for Major Burn Injury; 2. A press pass is required for access.

Frozen Plasma 109

Frozen Plasma Plasma Firefighter ED 109

EMDocs

FEBRUARY 3, 2025

Specifically, patients with SLE face an elevated risk of vascular disease due to higher rates of hypertension and hyperlipidemia, predisposing them to both macrovascular and microvascular events, such as TIA, stroke, and neuropathy (7-9). Renal Lupus nephritis is a common and significant complication of SLE. Antibodies (Basel). 2024;13(1):21.

ED 71

ED E-9-1-1 ALS OR 71

Don't Forget the Bubbles

APRIL 7, 2025

Clinical History and Examination A comprehensive history should focus on: Perinatal events: Breech presentation, birth asphyxia, neonatal hypoglycaemia , or jaundice. Growth and developmental milestones: Poor growth velocity, delayed bone age, or signs of hypothyroidism.

E-9-1-1 69

E-9-1-1 Plasma ALS OR 69

EMDocs

FEBRUARY 22, 2025

Although the concentration of chloride in the CSF is slightly higher than in plasma, measuring chloride (B) is not an accurate way to detect the presence of CSF. Loss of CSF into the circulatory system is unregulated and cannot be reabsorbed, leading to intracranial hypotension.

EMS 67

EMS E-9-1-1 OR Plasma 67

Core EM

JANUARY 16, 2025

This graph shows the gaseous equivalent volume of oxygen stored in the lungs, bound to hemoglobin, and dissolved in the plasma for people breathing room air (far left) vs the same people pre-oxygenated by breathing 100% O2 (far right), and then after they have desatted to 90% while apneic (center). Figure 7: (modified from Tanoubi 2009).

E-9-1-1 130

E-9-1-1 EMS ALS OR 130