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In the acute setting, it is postulated that withdrawal may be brought on by the rapid reversal and displacement of opioid receptors from drugs such as naloxone (Narcan). That is, they experienced nausea, vomiting, chills, myalgias, and diarrhea. 2022;23(1):4-9. Obeng S, Kamble SH, Reeves ME, et al. J Med Chem. 2020;63(1):433-439.
Profound increase in epinephrine concentration in plasma and cardiovascular stimulation after mu-opioid receptor blockade in opioid-addicted patients during barbiturate-induced anesthesia for acute detoxification. PMID: 19731165] Product Information: Narcan(R), naloxone. J Med Toxicol. 2016 Mar;12(1):107-10. Anesthesiology.
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